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Table 1 Baseline patient characteristics according to total patients, CRP and NLR level

From: Prognostic value of C-reactive protein and neutrophil-to-lymphocyte ratio in patients with hepatocellular carcinoma

Characteristics

Total patients (n = 318)

Patients grouped by CRP level (n = 318)

Patients grouped by NLR level (n = 318)

  

CRP ≤ 6.3 mg/L (n = 171)

CRP > 6.3 mg/L (n = 147)

NLR ≤ 2.3 (n = 129)

NLR > 2.3 (n = 189)

Sex (male:female)

240:78

122:49

118:29

93:36

147:42

Age (years)

58 (32–89)

59 (33–80)

58 (32–89)

58 (33–80)

59 (32–89)

Cause (HBV/HCV/Alcohol/Others, %)

242 (76.1)/ 33 (10.4)/ 25 (7.9) / 18 (5.7)

123 (71.9)/ 26 (15.2)/ 12 (7.0)/ 10 (5.8)

119 (81.0)/ 7 (4.8)/ 13 (8.8)/ 8 (5.4)

100 (77.5)/ 14 (10.9)/ 8 (6.2)/ 7 (5.4)

142 (75.1)/ 19 (10.1)/ 17 (9.0)/ 11 (5.8)

Platelet counts (×103/mm3)

139.6 ± 86.5

121.1 ± 63.9

161.1 ± 103.1

121.8 ± 64.9

151.7 ± 96.9

ALT (IU/L)

39.0 (1.0–2,430.0)

35.0 (1.0–2,430.0)

42.0 (6.0–503.0)

39.0 (1.0–2,430.0)

39.0 (6.0–503.0)

Total bilirubin (mg/dL)

1.0 (0.2–26.9)

0.9 (0.2–9.4)

1.2 (0.2–26.9)

0.9 (0.2–7.8)

1.1 (0.2–26.9)

Albumin (g/dL)

3.5 ± 0.6

3.7 ± 0.4

3.4 ± 0.5

3.6 ± 0.6

3.5 ± 0.6

Prothrombin time (%)

79.4 ± 18.0

81.3 ± 17.6

77.1 ± 18.2

80.4 ± 18.4

78.6 ± 17.7

Child-Pugh class (A/ B/ C, %)

200 (62.9)/ 91 (28.6)/ 27 (8.5)

128 (74.9)/ 36 (21.1)/ 7 (4.1)

72 (49.0)/ 55 (37.4)/ 20 (13.6)

99 (76.7)/ 26 (20.2)/ 4 (3.1)

101 (53.4)/ 65 (34.4)/ 23 (12.2)

Tumor size (cm)

5.5(0.8–26.5)

3.0 (0.8–18.6)

10.0 (1.0–26.5)

3.0 (0.8–17.4)

7.9 (1.3–26.5)

Tumor number, solitary (%)

144 (45.3)

93 (54.4)

51 (34.7)

74 (57.4)

70 (37.0)

Presence of PVT (%)

107 (33.6)

24 (14.0)

83 (56.5)

23 (17.8)

84 (44.4)

Presence of metastasis (%)

62 (19.5)

14 (8.2)

48 (32.7)

11 (8.5)

51 (27.0)

Tumor stage (I/ II/ III/ IVa/ IVb, %)

41 (12.9)/ 76 (23.8)/ 85 (26.7)/ 64 (20.1)/ 52 (16.4)

34 (19.9)/ 57 (33.3)/ 51 (29.8)/ 17 (9.9)/ 12 (7.0)

7 (4.8)/ 19 (12.9)/ 34 (23.1)/ 47 (32.0)/ 40 (27.2)

30 (23.3)/ 40 (31.0)/ 35 (27.1)/ 18 (14.0)/ 6 (4.7)

11 (5.8)/ 36 (19.0)/ 50 (26.5)/ 46 (24.3)/ 46 (24.3)

AFP (ng/mL)

92.3 (1.6–2,753,500.0)

28.9 (1.6–331,580.0)

350.0 (2.2–2,753,500.0)

32.3 (1.7–331,580.0)

207.1 (1.6–2,753,500.0)

CRP (mg/L)

4.7 (0.1–343.6)

1.2 (0.1–6.3)

24.9 (6.4–343.6)

1.7 (0.1–64.8)

14.3 (0.2–343.6)

NLR

2.6 (0.6–49.9)

1.8 (0.6–13.0)

4.0 (0.7–49.9)

1.5 (0.6–2.2)

3.8 (2.3–49.9)

  1. CRP, C-reactive protein; NLR, neutrophil-to-lymphocyte ratio; HBV, hepatitis B virus; HCV, hepatitis C virus; ALT, alanine aminotransferase; PVT, portal vein thrombosis; AFP, α-fetoprotein.