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Table 1 Baseline patient characteristics according to total patients, CRP and NLR level

From: Prognostic value of C-reactive protein and neutrophil-to-lymphocyte ratio in patients with hepatocellular carcinoma

Characteristics Total patients (n = 318) Patients grouped by CRP level (n = 318) Patients grouped by NLR level (n = 318)
   CRP ≤ 6.3 mg/L (n = 171) CRP > 6.3 mg/L (n = 147) NLR ≤ 2.3 (n = 129) NLR > 2.3 (n = 189)
Sex (male:female) 240:78 122:49 118:29 93:36 147:42
Age (years) 58 (32–89) 59 (33–80) 58 (32–89) 58 (33–80) 59 (32–89)
Cause (HBV/HCV/Alcohol/Others, %) 242 (76.1)/ 33 (10.4)/ 25 (7.9) / 18 (5.7) 123 (71.9)/ 26 (15.2)/ 12 (7.0)/ 10 (5.8) 119 (81.0)/ 7 (4.8)/ 13 (8.8)/ 8 (5.4) 100 (77.5)/ 14 (10.9)/ 8 (6.2)/ 7 (5.4) 142 (75.1)/ 19 (10.1)/ 17 (9.0)/ 11 (5.8)
Platelet counts (×103/mm3) 139.6 ± 86.5 121.1 ± 63.9 161.1 ± 103.1 121.8 ± 64.9 151.7 ± 96.9
ALT (IU/L) 39.0 (1.0–2,430.0) 35.0 (1.0–2,430.0) 42.0 (6.0–503.0) 39.0 (1.0–2,430.0) 39.0 (6.0–503.0)
Total bilirubin (mg/dL) 1.0 (0.2–26.9) 0.9 (0.2–9.4) 1.2 (0.2–26.9) 0.9 (0.2–7.8) 1.1 (0.2–26.9)
Albumin (g/dL) 3.5 ± 0.6 3.7 ± 0.4 3.4 ± 0.5 3.6 ± 0.6 3.5 ± 0.6
Prothrombin time (%) 79.4 ± 18.0 81.3 ± 17.6 77.1 ± 18.2 80.4 ± 18.4 78.6 ± 17.7
Child-Pugh class (A/ B/ C, %) 200 (62.9)/ 91 (28.6)/ 27 (8.5) 128 (74.9)/ 36 (21.1)/ 7 (4.1) 72 (49.0)/ 55 (37.4)/ 20 (13.6) 99 (76.7)/ 26 (20.2)/ 4 (3.1) 101 (53.4)/ 65 (34.4)/ 23 (12.2)
Tumor size (cm) 5.5(0.8–26.5) 3.0 (0.8–18.6) 10.0 (1.0–26.5) 3.0 (0.8–17.4) 7.9 (1.3–26.5)
Tumor number, solitary (%) 144 (45.3) 93 (54.4) 51 (34.7) 74 (57.4) 70 (37.0)
Presence of PVT (%) 107 (33.6) 24 (14.0) 83 (56.5) 23 (17.8) 84 (44.4)
Presence of metastasis (%) 62 (19.5) 14 (8.2) 48 (32.7) 11 (8.5) 51 (27.0)
Tumor stage (I/ II/ III/ IVa/ IVb, %) 41 (12.9)/ 76 (23.8)/ 85 (26.7)/ 64 (20.1)/ 52 (16.4) 34 (19.9)/ 57 (33.3)/ 51 (29.8)/ 17 (9.9)/ 12 (7.0) 7 (4.8)/ 19 (12.9)/ 34 (23.1)/ 47 (32.0)/ 40 (27.2) 30 (23.3)/ 40 (31.0)/ 35 (27.1)/ 18 (14.0)/ 6 (4.7) 11 (5.8)/ 36 (19.0)/ 50 (26.5)/ 46 (24.3)/ 46 (24.3)
AFP (ng/mL) 92.3 (1.6–2,753,500.0) 28.9 (1.6–331,580.0) 350.0 (2.2–2,753,500.0) 32.3 (1.7–331,580.0) 207.1 (1.6–2,753,500.0)
CRP (mg/L) 4.7 (0.1–343.6) 1.2 (0.1–6.3) 24.9 (6.4–343.6) 1.7 (0.1–64.8) 14.3 (0.2–343.6)
NLR 2.6 (0.6–49.9) 1.8 (0.6–13.0) 4.0 (0.7–49.9) 1.5 (0.6–2.2) 3.8 (2.3–49.9)
  1. CRP, C-reactive protein; NLR, neutrophil-to-lymphocyte ratio; HBV, hepatitis B virus; HCV, hepatitis C virus; ALT, alanine aminotransferase; PVT, portal vein thrombosis; AFP, α-fetoprotein.