Table 6 Surgical results and overall response
Dose level | ||||
|---|---|---|---|---|
1 | 2 | 3 | Total | |
Number of patients | 4 (100%) | 13 (100%) | 7 (100%) | 24 (100%) |
Surgery? | ||||
No | 1 (25%) | 2 (15%) | 3 (43%) | 6 (25%) |
Yes | 3 (75%) | 11 (85%) | 4 (57%) | 18 (75%) |
If so: | ||||
R0 | 2 (67%) | 8 (73%) | 4 (100%) | 14 (78%) |
Grading | ||||
G2 | 3 (27%) | 1 (25%) | 4 (22%) | |
G3 | 2 (67%) | 4 (36%) | 2 (50%) | 8 (44%) |
Information missing | 1 (33%) | 4 (36%) | 1 (25%) | 6 (33%) |
Response prior to surgery (RECIST) | ||||
N | 3 (100%) | 12 (100%) | 7 (100%) | 22 (100%) |
PR | 2 (67%) | 3 (25%) | 2 (29%) | 7 (32%) |
SD | 5 (42%) | 2 (29%) | 7 (32%) | |
PD | 1 (33%) | 2 (17%) | 2 (29%) | 1 (5%) |
NK/ND | 2 (17%) | 1 (14%) | 2 (9%) | |
Staging prior to surgery (UICC) | ||||
N | 4 (100%) | 12 (100%) | 7 (100%) | 23 (100%) |
II A | 4 (33%) | 1 (14%) | 5 (229%) | |
II B | 1 (8%) | 1 (14%) | 2 (9%) | |
III | 3 (75%) | 4 (33%) | 2 (29%) | 9 (39%) |
IV | 1 (14%) | 1 (4%) | ||
NK/ND | 1 (25%) | 3 (25%) | 2 (29%) | 6 (26%) |
Pathologic response [15] | ||||
N | 3 (100%) | 11 (100%) | 4 (100%) | 18 (100%) |
CR | 4 (36%) | 2 (50%) | 6 (33%) | |
PR | 1 (33%) | 4 (36%) | 2 (50%) | 7 (39%) |
SD | 1 (9%) | 1 (6%) | ||
PD | 1 (33%) | 1 (9%) | 2 (11%) | |
NK/ND | 1 (33%) | 1 (9%) | 2 (11%) | |
Staging after surgery (UICC) | ||||
N | 3 (100%) | 11 (100%) | 4 (100%) | 18 (100%) |
0 | 2 (18%) | 1 (25%) | 3 (17%) | |
I | 1 (9%) | 1 (25%) | 2 (11%) | |
II A | 1 (33%) | 2 (18%) | 3 (17%) | |
II B | 1 (33%) | 2 (18%) | 2 (50%) | 5 (28%) |
III | 1 (9%) | 1 (6%) | ||
NK/ND | 1 (33%) | 3 (27%) | 4 (22%) | |