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Table 4 Administration of radiochemotherapy

From: Prospective, open, multi-centre phase I/II trial to assess safety and efficacy of neoadjuvant radiochemotherapy with docetaxel and oxaliplatin in patients with adenocarcinoma of the oesophagogastric junction

 

Dose level

 
 

1

2

3

Total

Number of patients

4 (100%)

13 (100%)

7 (100%)

24 (100%)

Chemotherapy delay?

    

  No

3 (75%)

5 (38%)

5 (71%)

13 (54%)

  Yes

1 (25%)

8 (62%)

2 (29%)

11 (46%)

If yes, reason for delay:

    

  Administrative reason

1 (100%)

4 (50%)

1 (50%)

6 (55%)

  Adverse event

 

4 (50%)

1 (50%)

5 (45%)

Chemotherapy reduction?

    

  No

3 (75%)

11 (85%)

6 (86%)

20 (83%)

  Yes

1 (25%)

2 (15%)

1 (14%)

4 (17%)

If so, reason for reduction:

    

  Administrative reason

 

1 (50%)

 

1 (25%)

  Adverse event

1 (100%)

1 (50%)

1 (100%)

3 (75%)

Radiotherapy total dose (Gy)

    

  Mean (SD)

46.8 (4.41)

44.45 (10.68)

46.54 (2.63)

45.45 (8.07)

  Median (range)

47.7 (41.4–50.4)

45.0 (10.8–50.4)

45.0 (45.0–50.4)

45.0 (10.8–50.4)