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Table 3 Distribution of the study population and median overall survival according to the class of prognostic scores; Harrell’s concordance indexes (HCS)

From: Comparative performances of prognostic indexes for breast cancer patients presenting with brain metastases

 

Number of pts (%)

MOS (95% CI)

p

Hazard Ratio (95% CI)

HCS (95% CI)

RPA

     

1

26 (10.4)

25.6 M (18.4–32.9)

 

1

0.6783

2

166 (66.4)

10.4 M (8.9–12.6)

<0.001

2.16 (1.34–3.50)

(0.65–0.71)

3

58 (23.2)

2 M (1.4–3.1)

 

11.38 (6.57–19.70)

 

GPA

     

≥3

32 (12.8)

24.7 M (12.7–27.1)

 

1

0.658

1.5-2.5

116 (46.4)

12.3 M (10.1–15.1)

<0.001

1.70 (1.09–2.65)

(0.62–0.69)

0-1

102 (40.8)

4.2 M (3.1–5.4)

 

4.15 (2.62–6.55)

 

BS-BM

     

3

31 (12.4)

21.6 M (12.7–25.8)

<0.001

1

 

2

68 (27.2)

12.7 M (9.7–18.4)

 

1.30 (0.81–2.08)

0.6803

1

96 (38.4)

8.7 M (6.1–12.3)

 

2.20 (1.41–3.46)

(0.64–0.72)

0

55 (22.0)

2.2 M (1.4–3.6)

 

6.99 (4.25–11.47)

 

P1PS

     

0–1

95 (38.0)

16.4 M (11.9–23.3)

 

1

0.6251

2–3

64 (25.6)

5.9 M (3.4–8.4)

<0.001

2.89 (2.01–4.14)

(0.58–0.66)

Not available

91 (36.4)

    

Breast GPA

     

3.5-4

53 (21.2)

18.4 M (12.4–23.3)

 

1

0.6587

3

90 (36.0)

10.3 M (8.4–13.7)

<0.001

1.37 (0.95–2.00)

(0.62–0.69)

1.5-2.5

76 (30.4)

5.7 M (4–8)

 

2.09 (1.43–3.06)

 

0-1

31 (12.4)

2.3 M (1–4.1)

 

5.75 (3.56–9.27)

 

Breast RPA

     

1

20 (8.0)

21.3 M (9.7–53.9)

 

1

0.6037

2

192 (76.8)

9.8 M (8.4–12.1)

<0.001

2.05 (1.20–3.50)

(0.57–0.63)

3

38 (15.2)

2.3 M (1.8–4.3)

 

6.84 (3.69–12.72)

 

Le Scodan Score

     

1

89 (35.6)

15.2 M (11.5–19.4)

 

1

0.6239

2

49 (19.6)

9.7 M (7.5–12.4)

<0.001

1.32 (0.91–1.92)

(0.58–0.66)

3

112 (44.8)

4.2 M (3.3–6.1)

 

1.92 (1.43–2.59)

 
  1. CI, Confidence Interval. MOS, Median Overall Survival (from brain metastases diagnosis). M, months. Pts, patients.