PSA kinetics and overall survival. (A) Waterfall plot showing the maximal PSA changes (%) from baseline during personalized peptide vaccination (PPV) at any time point. (B) Overall survival by >50% PSA decline. (C) The ratio of PSADT changes for each patient pre- and during PPV is plotted. The ratio of PSADT changes was calculated by dividing PSADT during treatment by pre-treatment PSADT. A ratio greater than 2 indicates prolongation of PSADT. (D) Overall survival by prolongation of PSDT. (E) Longitudinal average PSA changes (%) before and during PPV. Green histograms: Responder group (alive for more than 20 months). Red histograms: Non-responder group (death within 12 months). Gray histograms: Other group.