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Table 3 Univariable Poisson regression associations with hot flash frequency (3A) and ordinal regression associations with hot flash severity (3B)

From: Hot flashes are not predictive for serum concentrations of tamoxifen and its metabolites

3A Univariable (N = 109) Inter. Pre-M. (N = 56) Post-M & PTHF (N = 18) Post-M & no PTHF (N = 35)
  Coef SE p-value p-value Coef SE p-value Coef SE p-value Coef SE p-value
Tamoxifen 0.002 0.0024 0.41 0.03 -0.0045 0.004 0.27 0.012 0.0038 0.01 0.0058 0.0044 0.19
N-desmethyltamoxifen -0.00002 0.0013 0.99 0.13 -0.0013 0.002 0.50 0.0053 0.002 0.02 -0.0014 0.0031 0.66
Endoxifen -0.015 0.022 0.50 0.01 -0.069 0.03 0.03 0.085 0.028 0.01 -0.0021 0.05 0.97
4-Hydroxytamoxifen -0.05 0.14 0.73 0.03 -0.3 0.19 0.13 0.63 0.17 0.002 -0.056 0.37 0.88
Post-M & PTHF v pre-M 0.13 0.27 0.67           
Post-M & no PTHF v pre-M -0.14 0.24            
Age -0.0059 0.0098 0.55           
Estradiol concentration -0.12 0.095 0.21           
BMI 0.048 0.023 0.04           
Tamoxifen duration 0.084 0.087 0.34           
CYP2D6: EM versus I/PM -0.11 0.21 0.61           
3B Univariable (N = 109) Inter. Pre-M. (N = 56) Post-M & PTHF (N = 18) Post-M & no PTHF (N = 35)
  Coef SE p-value p-value Coef SE p-value Coef SE p-value Coef SE p-value
Tamoxifen 0.0026 0.0045 0.57 0.60 0.0026 0.0065 0.69 0.018 0.014 0.16 0.0019 0.0075 0.80
N-desmethyltamoxifen -0.00043 0.0022 0.85 0.30 -0.00048 0.003 0.88 0.01 0.0067 0.11 -0.0024 0.0039 0.53
Endoxifen -0.013 0.039 0.73 0.72 -0.027 0.055 0.62 0.044 0.092 0.63 0.025 0.072 0.73
4-Hydroxytamoxifen -0.20 0.25 0.43 0.64 -0.11 0.31 0.74 0.39 0.70 0.58 -0.36 0.52 0.48
Post-M & PTHF v pre-M 0.94 0.51 0.11           
Post-M & no PTHF v pre-M -0.17 0.42            
Age -0.018 0.017 0.31           
Estradiol concentration -0.34 0.14 0.02           
BMI 0.19 0.048 <0.0001           
Tamoxifen duration 0.25 0.18 0.15           
CYP2D6: EM versus I/PM 0.0058 0.41 0.99           
  1. Inter, Interaction; pre-M, Pre-menopausal patients; post-M, Post-menopausal patients; PTHF, Pre-treatment hot flashes; v, Versus; Coef, Coefficient; SE, Standard error; BMI, Body mass index; EM, Extensive metabolizers; I/PM, Intermediate to poor metabolizers.
  2. For tamoxifen and its metabolites the test of interaction with menopausal and PTHF status, and the within-group associations are also reported.