Table 3 Interaction between TP53 SNPs and lifestyle factors in Taiyuan lung cancer study
| Â | Â | Cases | Controls | Crude OR (95% CI) | Adjusted OR* (95% CI) |
|---|---|---|---|---|---|
Smoking | rs2078486 | Â | Â | Â | Â |
  No | CC | 95 | 147 | 1 | 1 |
  No | TC or TT | 70 | 127 | 0.85 (0.58, 1.26) | 0.93 (0.62, 1.39) |
  Yes | CC | 91 | 103 | 1.37 (0.93, 2.00) | 3.58 (2.02, 6.36) |
  Yes | TC or TT | 99 | 71 | 2.16 (1.45, 3.22) | 6.00 (3.33, 10.81) |
  OR for interaction |  |  |  | 1.85 (1.05, 3.27) | 1.80 (0.99, 3.30) |
  RERI |  |  |  | 0.94 (0.14, 1.74) | 2.49 (−0.03, 5.01) |
Alcohol drinking | rs2078486 | Â | Â | Â | Â |
  No | CC | 147 | 184 | 1 | 1 |
  No | TC or TT | 124 | 148 | 1.05 (0.76, 1.45) | 1.06 (0.76, 1.48) |
  Yes | CC | 39 | 66 | 0.74 (0.47, 1.16) | 0.71 (0.42, 1.21) |
  Yes | TC or TT | 45 | 50 | 1.13 (0.71, 1.78) | 1.35 (0.79, 2.30) |
  OR for interaction |  |  |  | 1.45 (0.76, 2.78) | 1.79 (0.90, 3.58) |
  RERI |  |  |  | 0.34 (−0.27, 0.95) | 0.58 (−0.15, 1.30) |
Tea drinking | rs2078486 | Â | Â | Â | Â |
  Yes | CC | 65 | 107 | 1 | 1 |
  Yes | TC or TT | 75 | 91 | 1.36 (0.88, 2.09) | 1.44 (0.91, 2.28) |
  No | CC | 121 | 143 | 1.39 (0.94, 2.06) | 1.43 (0.92, 2.22) |
  No | TC or TT | 94 | 107 | 1.45 (0.96, 2.19) | 1.51 (0.94, 2.41) |
  OR for interaction |  |  |  | 0.77 (0.43, 1.35) | 0.73 (0.40, 1.32) |
  RERI |  |  |  | −0.30 (−1.08, 0.48) | −0.37 (−1.21, 0.48) |
Indoor air pollution | rs2078486 | Â | Â | Â | Â |
  Low | CC | 63 | 124 | 1 | 1 |
  Low | TC or TT | 41 | 105 | 0.77 (0.48, 1.23) | 0.78 (0.48, 1.28) |
  High | CC | 107 | 122 | 1.73 (1.16, 2.57) | 1.42 (0.92, 2.20) |
  High | TC or TT | 104 | 89 | 2.30 (1.52, 3.48) | 2.11 (1.35, 3.29) |
  OR for interaction |  |  |  | 1.73 (0.94, 3.18) | 1.89 (1.00, 3.56) |
  RERI |  |  |  | 0.81 (−0.03, 1.65) | 0.90 (0.11, 1.70) |
Smoking | rs1042522 | Â | Â | Â | Â |
  No | GG or CG | 120 | 216 | 1 | 1 |
  No | CC | 48 | 58 | 1.49 (0.96, 2.32) | 1.59 (1.00, 2.53) |
  Yes | GG or CG | 144 | 141 | 1.84 (1.33, 2.54) | 4.73 (2.78, 8.04) |
  Yes | CC | 51 | 31 | 2.96 (1.80, 4.88) | 8.00 (4.08, 15.71) |
  OR for interaction |  |  |  | 1.08 (0.55, 2.11) | 1.07 (0.52, 2.18) |
  RERI |  |  |  | 0.63 (−0.87, 2.14) | 2.69 (−1.64, 7.02) |
Alcohol drinking | rs1042522 | Â | Â | Â | Â |
  No | GG or CG | 200 | 263 | 1 | 1 |
  No | CC | 74 | 69 | 1.41 (0.97, 2.05) | 1.45 (0.98, 2.14) |
  Yes | GG or CG | 64 | 94 | 0.90 (0.62, 1.29) | 0.90 (0.57, 1.41) |
  Yes | CC | 25 | 20 | 1.64 (0.89, 3.04) | 1.86 (0.92, 3.76) |
  OR for interaction |  |  |  | 1.30 (0.61, 2.80) | 1.44 (0.63, 3.27) |
  RERI |  |  |  | 0.34 (−0.78, 1.45) | 0.52 (−0.82, 1.86) |
Tea drinking | rs1042522 | Â | Â | Â | Â |
  Yes | GG or CG | 100 | 159 | 1 | 1 |
  Yes | CC | 41 | 35 | 1.86 (1.11, 3.12) | 2.09 (1.21, 3.61) |
  No | GG or CG | 164 | 198 | 1.32 (0.95, 1.82) | 1.39 (0.95, 2.04) |
  No | CC | 58 | 54 | 1.71 (1.09, 2.67) | 1.81 (1.10, 2.97) |
  OR for interaction |  |  |  | 0.70 (0.36, 1.36) | 0.62 (0.31, 1.25) |
  RERI |  |  |  | −0.47 (−1.62, 0.68) | −0.67 (−1.99, 0.65) |
Indoor air pollution | rs1042522 | Â | Â | Â | Â |
  Low | GG or CG | 73 | 188 | 1 | 1 |
  Low | CC | 33 | 41 | 2.07 (1.22, 3.53) | 1.99 (1.14, 3.48) |
  High | GG or CG | 159 | 163 | 2.51 (1.78, 3.56) | 2.04 (1.40, 2.99) |
  High | CC | 56 | 46 | 3.14 (1.95, 5.04) | 2.76 (1.66, 4.58) |
  OR for interaction |  |  |  | 0.60 (0.30, 1.21) | 0.68 (0.33, 1.41) |
  RERI |  |  |  | −0.45 (−2.14, 1.24) | −0.28 (−1.88, 1.33) |