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Table 3 Interaction between TP53 SNPs and lifestyle factors in Taiyuan lung cancer study

From: TP53 genetic polymorphisms, interactions with lifestyle factors and lung cancer risk: a case control study in a Chinese population

   Cases Controls Crude OR (95% CI) Adjusted OR* (95% CI)
Smoking rs2078486     
  No CC 95 147 1 1
  No TC or TT 70 127 0.85 (0.58, 1.26) 0.93 (0.62, 1.39)
  Yes CC 91 103 1.37 (0.93, 2.00) 3.58 (2.02, 6.36)
  Yes TC or TT 99 71 2.16 (1.45, 3.22) 6.00 (3.33, 10.81)
  OR for interaction     1.85 (1.05, 3.27) 1.80 (0.99, 3.30)
  RERI     0.94 (0.14, 1.74) 2.49 (−0.03, 5.01)
Alcohol drinking rs2078486     
  No CC 147 184 1 1
  No TC or TT 124 148 1.05 (0.76, 1.45) 1.06 (0.76, 1.48)
  Yes CC 39 66 0.74 (0.47, 1.16) 0.71 (0.42, 1.21)
  Yes TC or TT 45 50 1.13 (0.71, 1.78) 1.35 (0.79, 2.30)
  OR for interaction     1.45 (0.76, 2.78) 1.79 (0.90, 3.58)
  RERI     0.34 (−0.27, 0.95) 0.58 (−0.15, 1.30)
Tea drinking rs2078486     
  Yes CC 65 107 1 1
  Yes TC or TT 75 91 1.36 (0.88, 2.09) 1.44 (0.91, 2.28)
  No CC 121 143 1.39 (0.94, 2.06) 1.43 (0.92, 2.22)
  No TC or TT 94 107 1.45 (0.96, 2.19) 1.51 (0.94, 2.41)
  OR for interaction     0.77 (0.43, 1.35) 0.73 (0.40, 1.32)
  RERI     −0.30 (−1.08, 0.48) −0.37 (−1.21, 0.48)
Indoor air pollution rs2078486     
  Low CC 63 124 1 1
  Low TC or TT 41 105 0.77 (0.48, 1.23) 0.78 (0.48, 1.28)
  High CC 107 122 1.73 (1.16, 2.57) 1.42 (0.92, 2.20)
  High TC or TT 104 89 2.30 (1.52, 3.48) 2.11 (1.35, 3.29)
  OR for interaction     1.73 (0.94, 3.18) 1.89 (1.00, 3.56)
  RERI     0.81 (−0.03, 1.65) 0.90 (0.11, 1.70)
Smoking rs1042522     
  No GG or CG 120 216 1 1
  No CC 48 58 1.49 (0.96, 2.32) 1.59 (1.00, 2.53)
  Yes GG or CG 144 141 1.84 (1.33, 2.54) 4.73 (2.78, 8.04)
  Yes CC 51 31 2.96 (1.80, 4.88) 8.00 (4.08, 15.71)
  OR for interaction     1.08 (0.55, 2.11) 1.07 (0.52, 2.18)
  RERI     0.63 (−0.87, 2.14) 2.69 (−1.64, 7.02)
Alcohol drinking rs1042522     
  No GG or CG 200 263 1 1
  No CC 74 69 1.41 (0.97, 2.05) 1.45 (0.98, 2.14)
  Yes GG or CG 64 94 0.90 (0.62, 1.29) 0.90 (0.57, 1.41)
  Yes CC 25 20 1.64 (0.89, 3.04) 1.86 (0.92, 3.76)
  OR for interaction     1.30 (0.61, 2.80) 1.44 (0.63, 3.27)
  RERI     0.34 (−0.78, 1.45) 0.52 (−0.82, 1.86)
Tea drinking rs1042522     
  Yes GG or CG 100 159 1 1
  Yes CC 41 35 1.86 (1.11, 3.12) 2.09 (1.21, 3.61)
  No GG or CG 164 198 1.32 (0.95, 1.82) 1.39 (0.95, 2.04)
  No CC 58 54 1.71 (1.09, 2.67) 1.81 (1.10, 2.97)
  OR for interaction     0.70 (0.36, 1.36) 0.62 (0.31, 1.25)
  RERI     −0.47 (−1.62, 0.68) −0.67 (−1.99, 0.65)
Indoor air pollution rs1042522     
  Low GG or CG 73 188 1 1
  Low CC 33 41 2.07 (1.22, 3.53) 1.99 (1.14, 3.48)
  High GG or CG 159 163 2.51 (1.78, 3.56) 2.04 (1.40, 2.99)
  High CC 56 46 3.14 (1.95, 5.04) 2.76 (1.66, 4.58)
  OR for interaction     0.60 (0.30, 1.21) 0.68 (0.33, 1.41)
  RERI     −0.45 (−2.14, 1.24) −0.28 (−1.88, 1.33)
  1. *Adjusted for age, gender, education, pack years of smoking, alcohol drinking, tea drinking and average income 10 years ago.
  2. Significant results were highlighted in bold.