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Table 1 Baseline characteristics, clinical course and mechanism of acquired resistance to EGFR-TKI in 26 patients

From: Mechanisms of acquired resistance to EGFR-tyrosine kinase inhibitor in Korean patients with lung cancer

SN Sex Age Histology EGFR mutation Changes in 2ndBx TKI PFS (months) OS (months) Bx site
    1st 2nd
1 M 80 ACC 19 del T790M + H1047L (PIK3CA) Gefitinib 34.7 65.7 RUL RUL
2 F 40 ACC 19 del T790M Gefitinib 12.7 17.1 LLL LN
3 F 48 ACC L858R T790M + AXL Gefitinib 11.5 38.9 LLL RLL
4 F 64 SqCC 19 del T790M + MET amp Gefitinib 7.8 14.2 RUL RUL
5 F 73 ACC L858R T790M + MET amp Gefitinib 13.1 47.7 RLL RLL
6 M 67 ACC L858R T790M Gefitinib 16.7 29.1 RUL Liver
7 M 53 ACC 19 del T790M Gefitinib 15.8 79.4 LUL LUL
8 F 48 ACC 19 del T790M Gefitinib 18.9 50.9 LN LN
9 F 57 ACC 19 del T790M Gefitinib 16.2 37.2 LLL Effusion
10 M 56 ACC 19 del T790M Gefitinib 14.8 28.9 RUL RUL
11 F 54 ACC 19 del T790M Gefitinib 28.7 58.2 RML LN
12 M 49 ACC L858R WT EGFR Gefitinib 6.6 89.2 RUL Liver
13 F 50 ACC 19 del MET amp Gefitinib 10.7 35.2 LN LUL
14 F 64 ACC L858R AXL Gefitinib 25.4 94.6 LUL RUL
15 M 67 ACC 19 del AXL Gefitinib 11.4 30.2 LUL Bone
16 M 59 ACC 19 del AXL Gefitinib 4.3 41.3 RLL LN
17 F 76 ACC 19 del AXL Gefitinib 10.7 31.0 RUL RUL
18 F 72 ACC 19 del None Gefitinib 26.1 46.4 RML RML
19 F 51 ACC L858R None Gefitinib 6.1 23.0 Bone LN
20 M 63 ACC L858R None Gefitinib 5.0 9.6 RLL RLL
21 F 73 ACC L858R None Gefitinib 3.9 25.1 LN LN
22 F 66 ACC L858R None Gefitinib 4.8 21.2 LUL LUL
23 F 57 ACC 19 del None Gefitinib 11.0 36.2 LUL LUL
24 M 65 ACC L858R None Gefitinib 5.4 20.6 RLL RLL
25 F 56 ACC 19 del CD56↑ Gefitinib 8.7 32.3 RUL RUL
26 M 50 ACC 19 del CD56↑ Gefitinib 5.9 15.4 LUL LUL
  1. ACC, Adenocarcinoma; SqCC, Squamous cell carcinoma; TKI, Tyrosine kinase inhibitor; PFS, Progression-free survival; OS, Overall survival; Bx, Biopsy; RUL, Right upper lobe; RML, Right middle lobe; RLL, Right lower lobe; LUL, Left upper lobe; LLL, Left lower lobe; LN, Lymph node; WT, Wild-type; ↑, increased expression.