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Table 5 Promoter methylation frequencies of SFRP2 , WIF-1 , DKK3 and SOX17 in relation with APC mutation

From: Promoter methylation of Wnt-antagonists in polypoid and nonpolypoid colorectal adenomas

  Nonpolypoid APC mutated Nonpolypoid APC WT p-value Polypoid APC mutated Polypoid APC WT p-value All adenomas APC mutated All adenomas APC WT p-value
SFRP2 94% (15/16) 93% (25/27) 1** 89% (23/26) 100% (18/18) 0.3** 91% (38/42) 96% (43/45) 0.4**
WIF-1 63% (10/16) 54% (14/26) 0.6** 96% (23/24) 73% (11/15) 0.06** 83% (33/40) 61% (25/41) 0.03*
DKK3 88% (14/16) 69% (18/26) 0.3** 100% (24/24) 93% (14/15) 0.4** 95% (38/40) 78% (32/41) 0.03*
SOX17 94% (15/16) 93% (25/27) 1** 100% (24/24) 100% (15/15) - 98% (39/40) 95% (40/42) 1**
All four combined 50% (8/16) 33% (8/24) 0.3* 88% (21/24) 67% (10/15) 0.2** 73% (29/40) 46% (18/39) 0.017*
  1. Results are shown for polypoid adenomas, nonpolypoid adenomas and all adenomas together, divided into samples that were APC mutated or APC wild type.
  2. All four combined; is considered positive if all four genes showed methylation. *chi-square based p-value **Fisher exact based p-value.