Table 5 Promoter methylation frequencies of SFRP2 , WIF-1 , DKK3 and SOX17 in relation with APC mutation
From: Promoter methylation of Wnt-antagonists in polypoid and nonpolypoid colorectal adenomas
| Â | Nonpolypoid APC mutated | Nonpolypoid APC WT | p-value | Polypoid APC mutated | Polypoid APC WT | p-value | All adenomas APC mutated | All adenomas APC WT | p-value |
|---|---|---|---|---|---|---|---|---|---|
SFRP2 | 94% (15/16) | 93% (25/27) | 1** | 89% (23/26) | 100% (18/18) | 0.3** | 91% (38/42) | 96% (43/45) | 0.4** |
WIF-1 | 63% (10/16) | 54% (14/26) | 0.6** | 96% (23/24) | 73% (11/15) | 0.06** | 83% (33/40) | 61% (25/41) | 0.03* |
DKK3 | 88% (14/16) | 69% (18/26) | 0.3** | 100% (24/24) | 93% (14/15) | 0.4** | 95% (38/40) | 78% (32/41) | 0.03* |
SOX17 | 94% (15/16) | 93% (25/27) | 1** | 100% (24/24) | 100% (15/15) | - | 98% (39/40) | 95% (40/42) | 1** |
All four combined | 50% (8/16) | 33% (8/24) | 0.3* | 88% (21/24) | 67% (10/15) | 0.2** | 73% (29/40) | 46% (18/39) | 0.017* |