Skip to main content

Advertisement

Table 3 Promoter methylation frequencies of SFRP2 , WIF-1 , DKK3 and SOX17 in relation with APC methylation

From: Promoter methylation of Wnt-antagonists in polypoid and nonpolypoid colorectal adenomas

  Nonpolypoid APC methylated Nonpolypoid APC unmethylated p-value Polypoid APC methylated Polypoid APC unmethylated p-value All adenomas APC methylated All adenomas APC unmethylated p-value
SFRP2 91% (30/33) 100% (7/7) 1** 93% (27/29) 93% (14/15) 1** 92% (57/62) 96% (21/22) 1**
WIF-1 59% (19/32) 43% (3/7) 0.7** 93% (22/25) 93% (12/14) 1** 71% (41/57) 68% (15/21) 1*
DKK3 72% (23/32) 86% (6/7) 0.7** 96% (24/25) 100% (14/14) 1** 83% (47/57) 96% (20/21) 0.3**
SOX17 91% (30/33) 100% (7/7) 1** 100% (25/25) 100% (14/14) - 95% (55/58) 100% (21/21) 0.6**
All four combined 37% (11/30) 43% (3/7) 1** 80% (20/25) 79% (11/14) 1** 56% (31/55) 67% (14/21) 0.4*
  1. Results are shown for polypoid adenomas, nonpolypoid adenomas and all adenomas together, divided into samples that were APC methylated or APC unmethylated.
  2. All four combined; is considered positive if all four genes showed methylation. *chi-square based p-value **Fisher exact based p-value.