Promoter methylation of Wnt-antagonists in polypoid and nonpolypoid colorectal adenomas

BMC Cancer

Table 1 Clinical characteristics of the patients used in this study

	Normal colorectal mucosa (n = 18)	Nonpolypoid adenomas (n = 44)	Polypoid adenomas (n = 44)	Carcinomas (n = 18)
Gender M/F	6/12	24/20	22/22	8/10
Age (years)	71.33 (49-84)	70.77 (50-87)	70.98 (40-90)	71.50 (51-91)
Location
Left colon		14	40	7
Right colon		30	4	10
Size		17.30 (5-100)	19.39 (6-64)	N/A
Paris classification
0-IIa		18
LST-G		7
LST-NG		19
0-Ip			44
Histology/AC-stage
Tubular/B1		21	22	2
Tubulovillous/B2		20	18	9
Villous/B3		2	4	1
Serrated/C2		1		5
C3				1
Dysplasia
Mild (LGD)		2	1
Moderate (LGD)		38	36
Severe (HGD)		4	7
Chromosome 5q loss		8/38	1/30
APC methylation		34/41	29/44
APC mutation		16/44	26/44

Right colon includes caecum, ascending and transverse colon; Left colon includes sigmoid, descending and splenic flexure; 0-IIa, slightly elevated adenoma; LST-G, Granular lateral spreading type adenoma; LST-NG, Non-granular lateral spreading type adenoma; 0-Ip, polypoid adenoma; AC-stage, Astler-Coller stage; LGD, low grade dysplasia; HGD, high grade dysplasia.

ISSN: 1471-2407