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Table 4 Univariate and multivariable analysis of prognostic indicators on overall survival and progress-free survival for synchronous metastatic colorectal cancer patients (N = 107)

From: The prognostic values of EGFR expression and KRAS mutation in patients with synchronous or metachronous metastatic colorectal cancer

Parameters Overall survival Progression-free survival
Univariate analysis Multivariable analysis Univariate analysis Multivariable analysis
HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value HR P value
Age (years) 1.160 (0.697–1.929) 0.568 1.561 (0.812–2.999) 0.182 1.160 (0.697–1.929) 0.568 1.561 (0.812–2.999) 0.182
(≥65 vs <65)
Sex 1.096 (0.661–1.818) 0.722 1.617 (0.790–3.307) 0.188 1.096 (0.661–1.818) 0.722 1.617 (0.790–3.307) 0.188
(Male vs Female)
Location 0.668 (0.357–1.252) 0.209 0.540 (0.198–1.473) 0.229 0.668 (0.357–1.252) 0.209 0.540 (0.198–1.473) 0.229
Rectum vs Colon
Tumor size 1.281 (0.784–2.094) 0.323 1.344 (0.683–2.644) 0.392 1.281 (0.784–2.094) 0.323 1.344 (0.683–2.644) 0.392
(≥5 cm vs <5 cm)
Tumor depth 1.072 (0.333–3.456) 0.907 0.506 (0.107–2.396) 0.391 1.072 (0.333–3.456) 0.907 0.506 (0.107–2.396) 0.391
T3 + T4 vs T1 + T2
LN metastasis 0.955 (0.541–1.684) 0.873 0.957 (0.488–1.879) 0.899 0.955 (0.541–1.684) 0.873 0.957 (0.488–1.879) 0.899
Yes vs No
Histology 1.307 (0.678–2.520) 0.425 1.629 (0.655–4.052) 0.294 1.307 (0.678–2.520) 0.425 1.629 (0.655–4.052) 0.294
PD vs MD + WD
Vascular invasion 1.092 (0.670–1.779) 0.724 0.826 (0.425–1.605) 0.573 1.092 (0.670–1.779) 0.724 0.826 (0.425–1.605) 0.573
Yes vs No
Perineurial invasion 1.510 (0.918–2.485) 0.105 1.396 (0.740–2.636) 0.303 1.510 (0.918–2.485) 0.105 1.396 (0.740–2.636) 0.303
Yes vs No
Pre-op CEA (ng/ml) 1.243 (0.623–2.482) 0.538 1.216 (0.418–3.540) 0.719 1.243 (0.623–2.482) 0.538 1.216 (0.418–3.540) 0.719
≥5/ vs <5
Post-op CEA (ng/ml) 0.731 (0.425–1.257) 0.257 0.988 (0.412–2.370) 0.979 0.731 (0.425–1.257) 0.257 0.988 (0.412–2.370) 0.979
≥5 vs <5
EGFR expression 0.945 (0.443–2.016) 0.883 0.648 (0.281–1.492) 0.308 0.945 (0.443–2.016) 0.883 0.648 (0.281–1.492) 0.308
Positive vs Negative
KRAS status 1.167 (0.707–1.925) 0.546 1.051 (0.554–1.992) 0.879 1.167 (0.707–1.925) 0.546 1.051 (0.554–1.992) 0.879
Mut vs WT