Parameters | Overall survival | Disease-free survival | ||||||
---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariable analysis | Univariate analysis | Multivariable analysis | |||||
HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
Age (years) | 0.691 (0.376–1.271) | 0.235 | 0.678 (0.303–1.515) | 0.343 | 0.829 (0.453–1.518) | 0.544 | 0.990 (0.439–2.231) | 0.980 |
(≥65 vs <65) | ||||||||
Sex | 0.933 (0.525–1.658) | 0.933 | 0.848 (0.409–1.755) | 0.656 | 1.018 (0.574–1.806) | 0.951 | 0.912 (0.433–1.921) | 0.808 |
(Male vs Female) | ||||||||
Location | 0.824 (0.454–1.495) | 0.523 | 0.985 (0.449–2.164) | 0.971 | 0.764 (0.421–1.388) | 0.378 | 1.033 (0.477–2.237) | 0.935 |
Rectum vs Colon | ||||||||
Tumor size | 0.897 (0.490–1.643) | 0.725 | 1.088 (0.512–2.310) | 0.826 | 0.896 (0.489–1.641) | 0.722 | 1.043 (0.471–2.311) | 0.917 |
(≥5 cm vs <5 cm) | ||||||||
Tumor depth | 0.972 (0.412–2.295) | 0.949 | 0.699 (0.238–2.050) | 0.514 | 1.047 (0.443–2.473) | 0.917 | 1.030 (0.356–2.980) | 0.956 |
T3 + T4 vs T1 + T2 | ||||||||
LN metastasis | 1.062 (0.588–1.923) | 0.844 | 0.989 (0.448–2.181) | 0.570 | 1.090 (0.604–1.965) | 0.776 | 0.813 (0.364–1.817) | 0.614 |
Yes vs No | ||||||||
Histology | 605 (0.216–1.695) | 0.339 | 0.628 (0.126–3.128) | 0.766 | 0.625 (0.223–1.7448) | 0.370 | 1.044 (0.210–5.200) | 0.958 |
PD vs MD + WD | ||||||||
AJCC stage | 1.062 (0.586–1.923) | 0.844 |  |  | 1.090 (0.604–1.965) | 0.776 |  |  |
III vs I&II | ||||||||
Vascular invasion | 1.643 (0.921–2.932) | 0.093 | 1.160 (0.519–2.629) | 0.707 | 1.555 (0.869–2.782) | 0.137 | 1.297 (0.549–3.068) | 0.553 |
Yes vs No | ||||||||
Perineurial invasion | 1.411 (0.785–2.536) | 0.250 | 1.107 (0.470–2.611) | 0.816 | 1.312 (0.731–2.354) | 0.363 | 0.933 (0.369–2.361) | 0.884 |
Yes vs No | ||||||||
Pre-op CEA (ng/ml) | 0.991 (0.530–1.851) | 0.977 | 0.680 (0.289–1.603) | 0.378 | 1.147 (0.616–2.134) | 0.666 | 0.901 (0.377–2.154) | 0.815 |
≥5/ vs <5 | ||||||||
Post-op CEA (ng/ml) | 1.432 (0.763–2.688) | 0.264 | 1.414 (0.561–3.562) | 0.462 | 1,479 (0.788–2.779) | 0.223 | 1.187 (0.454–3.101) | 0.727 |
≥5 vs <5 | ||||||||
EGFR expression | 3.577 (1.464–8.741) | 0.005 | 3.090 (1.130–8.445) | 0.028 | 4.609 (1.864–11.396) | 0.001 | 4.012 (1.477–10.900) | 0.006 |
Positive vs Negative | ||||||||
KRAS status | 1.249 (0.690–2.260) | 0.462 | 1.815 (0.823–4.004) | 0.140 | 1.066 (0.597–1.904) | 0.829 | 1.440 (0.656–.081) | 0.260 |
Mut vs WT |