Skip to main content

Table 3 Univariate and multivariable analysis of prognostic indicators on overall survival and disease-free survival for metachronous metastatic colorectal cancer patients (N = 98)

From: The prognostic values of EGFR expression and KRAS mutation in patients with synchronous or metachronous metastatic colorectal cancer

Parameters

Overall survival

Disease-free survival

Univariate analysis

Multivariable analysis

Univariate analysis

Multivariable analysis

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Age (years)

0.691 (0.376–1.271)

0.235

0.678 (0.303–1.515)

0.343

0.829 (0.453–1.518)

0.544

0.990 (0.439–2.231)

0.980

(≥65 vs <65)

Sex

0.933 (0.525–1.658)

0.933

0.848 (0.409–1.755)

0.656

1.018 (0.574–1.806)

0.951

0.912 (0.433–1.921)

0.808

(Male vs Female)

Location

0.824 (0.454–1.495)

0.523

0.985 (0.449–2.164)

0.971

0.764 (0.421–1.388)

0.378

1.033 (0.477–2.237)

0.935

Rectum vs Colon

Tumor size

0.897 (0.490–1.643)

0.725

1.088 (0.512–2.310)

0.826

0.896 (0.489–1.641)

0.722

1.043 (0.471–2.311)

0.917

(≥5 cm vs <5 cm)

Tumor depth

0.972 (0.412–2.295)

0.949

0.699 (0.238–2.050)

0.514

1.047 (0.443–2.473)

0.917

1.030 (0.356–2.980)

0.956

T3 + T4 vs T1 + T2

LN metastasis

1.062 (0.588–1.923)

0.844

0.989 (0.448–2.181)

0.570

1.090 (0.604–1.965)

0.776

0.813 (0.364–1.817)

0.614

Yes vs No

Histology

605 (0.216–1.695)

0.339

0.628 (0.126–3.128)

0.766

0.625 (0.223–1.7448)

0.370

1.044 (0.210–5.200)

0.958

PD vs MD + WD

AJCC stage

1.062 (0.586–1.923)

0.844

  

1.090 (0.604–1.965)

0.776

  

III vs I&II

Vascular invasion

1.643 (0.921–2.932)

0.093

1.160 (0.519–2.629)

0.707

1.555 (0.869–2.782)

0.137

1.297 (0.549–3.068)

0.553

Yes vs No

Perineurial invasion

1.411 (0.785–2.536)

0.250

1.107 (0.470–2.611)

0.816

1.312 (0.731–2.354)

0.363

0.933 (0.369–2.361)

0.884

Yes vs No

Pre-op CEA (ng/ml)

0.991 (0.530–1.851)

0.977

0.680 (0.289–1.603)

0.378

1.147 (0.616–2.134)

0.666

0.901 (0.377–2.154)

0.815

≥5/ vs <5

Post-op CEA (ng/ml)

1.432 (0.763–2.688)

0.264

1.414 (0.561–3.562)

0.462

1,479 (0.788–2.779)

0.223

1.187 (0.454–3.101)

0.727

≥5 vs <5

EGFR expression

3.577 (1.464–8.741)

0.005

3.090 (1.130–8.445)

0.028

4.609 (1.864–11.396)

0.001

4.012 (1.477–10.900)

0.006

Positive vs Negative

KRAS status

1.249 (0.690–2.260)

0.462

1.815 (0.823–4.004)

0.140

1.066 (0.597–1.904)

0.829

1.440 (0.656–.081)

0.260

Mut vs WT