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Table 3 Univariate and multivariable analysis of prognostic indicators on overall survival and disease-free survival for metachronous metastatic colorectal cancer patients (N = 98)

From: The prognostic values of EGFR expression and KRAS mutation in patients with synchronous or metachronous metastatic colorectal cancer

Parameters Overall survival Disease-free survival
Univariate analysis Multivariable analysis Univariate analysis Multivariable analysis
HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value
Age (years) 0.691 (0.376–1.271) 0.235 0.678 (0.303–1.515) 0.343 0.829 (0.453–1.518) 0.544 0.990 (0.439–2.231) 0.980
(≥65 vs <65)
Sex 0.933 (0.525–1.658) 0.933 0.848 (0.409–1.755) 0.656 1.018 (0.574–1.806) 0.951 0.912 (0.433–1.921) 0.808
(Male vs Female)
Location 0.824 (0.454–1.495) 0.523 0.985 (0.449–2.164) 0.971 0.764 (0.421–1.388) 0.378 1.033 (0.477–2.237) 0.935
Rectum vs Colon
Tumor size 0.897 (0.490–1.643) 0.725 1.088 (0.512–2.310) 0.826 0.896 (0.489–1.641) 0.722 1.043 (0.471–2.311) 0.917
(≥5 cm vs <5 cm)
Tumor depth 0.972 (0.412–2.295) 0.949 0.699 (0.238–2.050) 0.514 1.047 (0.443–2.473) 0.917 1.030 (0.356–2.980) 0.956
T3 + T4 vs T1 + T2
LN metastasis 1.062 (0.588–1.923) 0.844 0.989 (0.448–2.181) 0.570 1.090 (0.604–1.965) 0.776 0.813 (0.364–1.817) 0.614
Yes vs No
Histology 605 (0.216–1.695) 0.339 0.628 (0.126–3.128) 0.766 0.625 (0.223–1.7448) 0.370 1.044 (0.210–5.200) 0.958
PD vs MD + WD
AJCC stage 1.062 (0.586–1.923) 0.844    1.090 (0.604–1.965) 0.776   
III vs I&II
Vascular invasion 1.643 (0.921–2.932) 0.093 1.160 (0.519–2.629) 0.707 1.555 (0.869–2.782) 0.137 1.297 (0.549–3.068) 0.553
Yes vs No
Perineurial invasion 1.411 (0.785–2.536) 0.250 1.107 (0.470–2.611) 0.816 1.312 (0.731–2.354) 0.363 0.933 (0.369–2.361) 0.884
Yes vs No
Pre-op CEA (ng/ml) 0.991 (0.530–1.851) 0.977 0.680 (0.289–1.603) 0.378 1.147 (0.616–2.134) 0.666 0.901 (0.377–2.154) 0.815
≥5/ vs <5
Post-op CEA (ng/ml) 1.432 (0.763–2.688) 0.264 1.414 (0.561–3.562) 0.462 1,479 (0.788–2.779) 0.223 1.187 (0.454–3.101) 0.727
≥5 vs <5
EGFR expression 3.577 (1.464–8.741) 0.005 3.090 (1.130–8.445) 0.028 4.609 (1.864–11.396) 0.001 4.012 (1.477–10.900) 0.006
Positive vs Negative
KRAS status 1.249 (0.690–2.260) 0.462 1.815 (0.823–4.004) 0.140 1.066 (0.597–1.904) 0.829 1.440 (0.656–.081) 0.260
Mut vs WT