Figure 7

Schematic representation of MMP-9- and/or uPAR-mediated glioma cell migration that utilizes the α9β1-iNOS pathway. In glioma cells, uPAR and MMP-9 upregulate iNOS levels via their interactions with α9β1 integrin, which contributes to glioma cell migration. MU-sh treatment reduced α9β1 integrin levels and, in turn, reduced iNOS, an enzyme that produces NO.