Skip to main content

Table 3 Associations between telomere length a and worst biopsy diagnosis

From: Measuring telomere length for the early detection of precursor lesions of esophageal squamous cell carcinoma

  

Esophagitis

Low-grade dysplasiab

High-grade dysplasiac

 

Controls

Cases

OR (95% CI)

Cases

OR (95% CI)

Cases

OR (95% CI)

Unadjusted

       

  Continuousd

92

50

0.90 (0.68-1.18)

37

1.14 (0.86-1.51)

52

1.14 (0.89-1.46)

  Quartiles

       

   <0.784

23

10

ref

4

ref

10

ref

   0.784 - <0.925

23

24

2.40 (0.94-6.13)

14

3.50 (1.00-12.25)

14

1.40 (0.52-3.79)

   0.925 - <1.047

23

5

0.50 (0.15-1.69)

9

2.25 (0.61-8.36)

13

1.30 (0.48-3.56)

   ≥1.047

23

11

1.10 (0.39-3.09)

10

2.50 (0.68-9.13)

15

1.50 (0.56-4.03)

   p-trend

  

0.031

 

0.224

 

0.870

Adjustede

       

   Continuousd

92

50

0.91 (0.68-1.21)

37

1.16 (0.87-1.54)

52

1.20 (0.92-1.56)

   Quartiles

       

   <0.784

23

10

ref

4

ref

10

ref

   0.784 - <0.925

23

24

2.46 (0.89-6.80)

14

4.80 (1.26-18.35)

14

1.51 (0.54-4.24)

   0.925 - <1.047

23

5

0.59 (0.16-2.13)

9

3.07 (0.78-12.06)

13

1.50 (0.52-4.27)

   ≥1.047

23

11

1.08 (0.36-3.28)

10

3.05 (0.80-11.66)

15

1.83 (0.65-5.12)

   p-trend

  

0.060

 

0.107

 

0.713

  1. aCalculated as telomeric DNA (T) divided by amount of single-copy control gene DNA (S) to produce the relative measurement of telomere length (T/S ratio).
  2. bLow-grade dysplasia category includes mild dysplasia cases.
  3. cHigh-grade dysplasia category includes moderate and severe dysplasia cases.
  4. dContinuous telomere length scaled by half the interquartile range based on the distribution among the normal controls.
  5. eModels adjusted for age, sex, BMI, tobacco smoking, alcohol drinking, and hypertension.
  6. Abbreviations: OR, odds ratio; CI, confidence interval; BMI, body mass index.
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us