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Table 3 Associations between telomere length a and worst biopsy diagnosis

From: Measuring telomere length for the early detection of precursor lesions of esophageal squamous cell carcinoma

   Esophagitis Low-grade dysplasiab High-grade dysplasiac
  Controls Cases OR (95% CI) Cases OR (95% CI) Cases OR (95% CI)
Unadjusted        
  Continuousd 92 50 0.90 (0.68-1.18) 37 1.14 (0.86-1.51) 52 1.14 (0.89-1.46)
  Quartiles        
   <0.784 23 10 ref 4 ref 10 ref
   0.784 - <0.925 23 24 2.40 (0.94-6.13) 14 3.50 (1.00-12.25) 14 1.40 (0.52-3.79)
   0.925 - <1.047 23 5 0.50 (0.15-1.69) 9 2.25 (0.61-8.36) 13 1.30 (0.48-3.56)
   ≥1.047 23 11 1.10 (0.39-3.09) 10 2.50 (0.68-9.13) 15 1.50 (0.56-4.03)
   p-trend    0.031   0.224   0.870
Adjustede        
   Continuousd 92 50 0.91 (0.68-1.21) 37 1.16 (0.87-1.54) 52 1.20 (0.92-1.56)
   Quartiles        
   <0.784 23 10 ref 4 ref 10 ref
   0.784 - <0.925 23 24 2.46 (0.89-6.80) 14 4.80 (1.26-18.35) 14 1.51 (0.54-4.24)
   0.925 - <1.047 23 5 0.59 (0.16-2.13) 9 3.07 (0.78-12.06) 13 1.50 (0.52-4.27)
   ≥1.047 23 11 1.08 (0.36-3.28) 10 3.05 (0.80-11.66) 15 1.83 (0.65-5.12)
   p-trend    0.060   0.107   0.713
  1. aCalculated as telomeric DNA (T) divided by amount of single-copy control gene DNA (S) to produce the relative measurement of telomere length (T/S ratio).
  2. bLow-grade dysplasia category includes mild dysplasia cases.
  3. cHigh-grade dysplasia category includes moderate and severe dysplasia cases.
  4. dContinuous telomere length scaled by half the interquartile range based on the distribution among the normal controls.
  5. eModels adjusted for age, sex, BMI, tobacco smoking, alcohol drinking, and hypertension.
  6. Abbreviations: OR, odds ratio; CI, confidence interval; BMI, body mass index.