5y OS | p† | 5y DFS | p† | 5y LRC | p† | 5y DMFS | p† | |
---|---|---|---|---|---|---|---|---|
Age (years) | ||||||||
<60 | 85.7 | .647 | 69.3 | .240 | 82.7 | .201 | 71.3 | .349 |
≥ 60 | 82.8 | 80.4 | 94.4 | 80.3 | ||||
Gender | ||||||||
Male | 83.2 | .477 | 70.4 | .412 | 84.0 | .365 | 70.4 | .155 |
Female | 87.7 | 79.2 | 92.5 | 84.1 | ||||
ECOG score | ||||||||
0 | 87.5 | .561 | 80.0 | .388 | 94.9 | .218 | 80.0 | .506 |
1–2 | 83.5 | 70.5 | 83.4 | 72.3 | ||||
Clinical T stage | ||||||||
T2 | 77.9 | .881 | 64.9 | .951 | 90.9 | .991 | 64.9 | .705 |
T3 | 84.9 | 73.0 | 85.8 | 73.9 | ||||
T4 | 90.9 | 81.8 | 90.0 | 90.9 | ||||
Clinical N stage | ||||||||
N (−) | 90.5 | .208 | 81.0 | .229 | 94.7 | .115 | 81.0 | .301 |
N (+) | 82.9 | 70.5 | 84.0 | 72.2 | ||||
Distance from anal verge | ||||||||
≤ 2 cm | 76.7 | .296 | 67.9 | .780 | 87.9 | .199 | 67.9 | .650 |
2–5 cm | 83.9 | 70.9 | 76.7 | 72.7 | ||||
> 5 cm | 92.2 | 78.6 | 92.6 | 80.5 | ||||
Pretreatment CEA | ||||||||
≤ 5 ng/ml | 86.8 | .617 | 77.6 | .162 | 91.0 | .081 | 78.5 | .213 |
> 5 ng/ml | 79.9 | 62.8 | 76.6 | 65.3 | ||||
Type of surgery | ||||||||
LAR | 89.5 | <.001 | 75.6 | <.001 | 88.8 | <.001 | 77.1 | <.001 |
APR | 34.3 | 40.0 | 57.1 | 40.0 | ||||
Patholgic response | ||||||||
None/Minimal | 83.7 | .228 | 62.8 | .096 | 78.2 | .073 | 64.9 | .125 |
Moderate | 80.1 | 74.9 | 89.2 | 75.7 | ||||
Near total | 95.8 | 86.2 | 93.8 | 86.4 | ||||
ypT stage | ||||||||
Tis/T1 | 92.3 | .080 | 84.6 | .036 | 92.3 | .073 | 84.6 | .069 |
T2 | 93.3 | 83.8 | 95.6 | 83.8 | ||||
T3 | 74.8 | 63.1 | 76.9 | 65.4 | ||||
ypN stage | ||||||||
N0 | 87.4 | <.001 | 85.5 | <.001 | 93.4 | <.001 | 86.7 | <.001 |
N1 | 85.9 | 53.2 | 76.3 | 55.0 | ||||
N2 | 57.1 | 36.0 | 57.1 | 36.0 | ||||
Downstage | ||||||||
Yes | 87.2 | .120 | 85.1 | <.001 | 84.3 | .213 | 86.5 | <.001 |
No | 80.6 | 56.6 | 87.9 | 57.8 | ||||
Lymphatic invasion | ||||||||
Yes | 75.8 | .065 | 45.1 | .004 | 54.7 | <.001 | 45.1 | .002 |
No | 85.6 | 76.9 | 91.4 | 78.5 | ||||
Vascular invasion | ||||||||
Yes | 71.4 | .047 | 38.1 | .026 | 57.1 | .002 | 38.1 | .017 |
No | 85.1 | 74.7 | 87.7 | 76.2 | ||||
Perinerual invasion | ||||||||
Yes | 61.0 | <.001 | 32.1 | <.001 | 53.3 | <.001 | 32.1 | <.001 |
No | 88.6 | 79.5 | 91.4 | 81.1 | ||||
Circumferential resection margin | ||||||||
≤ 1.5 mm | 59.4 | <.001 | 48.4 | <.001 | 70.7 | <.001 | 48.4 | <.001 |
> 1.5 mm | 91.6 | 79.3 | 90.6 | 81.1 | ||||
Distal resection margin | ||||||||
≤ 7 mm | 92.1 | .010 | 73.0 | .525 | 88.3 | .116 | 74.1 | .559 |
> 7 mm | 75.5 | 73.4 | 84.3 | 75.1 |