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Table 2 Results of univariate analysis

From: The influence of the treatment response on the impact of resection margin status after preoperative chemoradiotherapy in locally advanced rectal cancer

 

5y OS

p†

5y DFS

p†

5y LRC

p†

5y DMFS

p†

Age (years)

        

 <60

85.7

.647

69.3

.240

82.7

.201

71.3

.349

 ≥ 60

82.8

 

80.4

 

94.4

 

80.3

 

Gender

        

 Male

83.2

.477

70.4

.412

84.0

.365

70.4

.155

 Female

87.7

 

79.2

 

92.5

 

84.1

 

ECOG score

        

 0

87.5

.561

80.0

.388

94.9

.218

80.0

.506

 1–2

83.5

 

70.5

 

83.4

 

72.3

 

Clinical T stage

        

 T2

77.9

.881

64.9

.951

90.9

.991

64.9

.705

 T3

84.9

 

73.0

 

85.8

 

73.9

 

 T4

90.9

 

81.8

 

90.0

 

90.9

 

Clinical N stage

        

 N (−)

90.5

.208

81.0

.229

94.7

.115

81.0

.301

 N (+)

82.9

 

70.5

 

84.0

 

72.2

 

Distance from anal verge

        

 ≤ 2 cm

76.7

.296

67.9

.780

87.9

.199

67.9

.650

 2–5 cm

83.9

 

70.9

 

76.7

 

72.7

 

 > 5 cm

92.2

 

78.6

 

92.6

 

80.5

 

Pretreatment CEA

        

 ≤ 5 ng/ml

86.8

.617

77.6

.162

91.0

.081

78.5

.213

 > 5 ng/ml

79.9

 

62.8

 

76.6

 

65.3

 

Type of surgery

        

 LAR

89.5

<.001

75.6

<.001

88.8

<.001

77.1

<.001

 APR

34.3

 

40.0

 

57.1

 

40.0

 

Patholgic response

        

 None/Minimal

83.7

.228

62.8

.096

78.2

.073

64.9

.125

 Moderate

80.1

 

74.9

 

89.2

 

75.7

 

 Near total

95.8

 

86.2

 

93.8

 

86.4

 

ypT stage

        

 Tis/T1

92.3

.080

84.6

.036

92.3

.073

84.6

.069

 T2

93.3

 

83.8

 

95.6

 

83.8

 

 T3

74.8

 

63.1

 

76.9

 

65.4

 

ypN stage

        

 N0

87.4

<.001

85.5

<.001

93.4

<.001

86.7

<.001

 N1

85.9

 

53.2

 

76.3

 

55.0

 

 N2

57.1

 

36.0

 

57.1

 

36.0

 

Downstage

        

 Yes

87.2

.120

85.1

<.001

84.3

.213

86.5

<.001

 No

80.6

 

56.6

 

87.9

 

57.8

 

Lymphatic invasion

        

 Yes

75.8

.065

45.1

.004

54.7

<.001

45.1

.002

 No

85.6

 

76.9

 

91.4

 

78.5

 

Vascular invasion

        

 Yes

71.4

.047

38.1

.026

57.1

.002

38.1

.017

 No

85.1

 

74.7

 

87.7

 

76.2

 

Perinerual invasion

        

 Yes

61.0

<.001

32.1

<.001

53.3

<.001

32.1

<.001

 No

88.6

 

79.5

 

91.4

 

81.1

 

Circumferential resection margin

        

 ≤ 1.5 mm

59.4

<.001

48.4

<.001

70.7

<.001

48.4

<.001

 > 1.5 mm

91.6

 

79.3

 

90.6

 

81.1

 

Distal resection margin

        

 ≤ 7 mm

92.1

.010

73.0

.525

88.3

.116

74.1

.559

 > 7 mm

75.5

 

73.4

 

84.3

 

75.1

 
  1. values are percentages of patients; †log rank test; 5y, 5-year; OS, overall survival; DFS, disease-free survival; LRC, locoregional control rates; DMFS, distant metastasis-free survival; ECOG, Eastern Cooperative Oncology Group; CEA, carcinoembryonic antigen; LAR, Low anterior resection; APR,Abdominoperineal resection.