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Figure 4 | BMC Cancer

Figure 4

From: Association of cellular and molecular responses in the rat mammary gland to 17β-estradiol with susceptibility to mammary cancer

Figure 4

Rat strain-specific effects of 17β-estradiol on luminal ectasia and expression of milk proteins. Representative fluorescent images of mammary tissues from ACI and BN rats, either sham treated (Ctrl) or treated with E2 for 1, 3 or 12 weeks (n = 3). Nuclei were identified by staining DNA with DAPI (blue), luminal epithelial cells by immunostaining for K8 (red), and milk proteins were identified by immunostaining using a polyclonal antibody generated against milk specific proteins (green). Note that the mammary glands from E2 treated BN rats exhibit prominent ectatic lumens containing immunoreactive milk protein(s). Scale bars, 50 μm.

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