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Table 2 Clinicopathological Variables and ZEB1 and E-cadherin expression in HCC

From: Clinical implication of ZEB-1 and E-cadherin expression in hepatocellular carcinoma (HCC)

   ZEB1 E-cadherin
Variable Total no. (n = 108) positive (n = 23) negative (n = 85) p-value preserved (n = 64) reduced (n = 44) p-value
Gender        
Male 85 18 67 0.996 47 38 0.107
Female 23 5 18   17 6  
Tumor size (mm)        
4.5 cm 33 10 27 0.227 21 16 0.702
<4.5 cm 75 13 58   43 28  
Vascular invasion        
Present 38 13 25 0.016 21 17 0.533
Absent 70 10 60   43 27  
Infiltration into capsule (Fc-inf)        
Present 84 18 66 0.95 51 33 0.565
Absent 24 5 19   13 11  
Intrahepatic metastasis        
Present 27 9 18 0.078 13 33 <0.001
Absent 81 14 67   51 11  
Gross classification*        
Localized 69 13 56 0.095 43 26 0.389
Invasive 29 10 19   21 18  
Differentiation*        
Well 18 3 15 0.5 9 9 0.717
Moderate 76 15 61   46 30  
Poor 12 4 8   7 5  
PIVKA II level (mAU/ml) (n = 91)        
Normal (40 ) 23 5 18 0.906 16 7 0.36
High (>40 ) 68 14 54   40 28  
AFP level (ng/ml) (n = 95)        
Normal (20 ) 48 10 38 0.837 29 19 0.732
High (>20 ) 47 9 38   30 17  
Pathological TMN Stage*        
I + II + III 88 15 73 0.023 56 32 0.05
IV 20 8 12   8 12  
Immunohistochemical staining        
ZEB-1        0.027
Positive 23   9   14   
negative 80     55 30  
  1. *The histological grade of each tumor and the tumor staging were determined by the General Rules for the Clinical and Pathological Study of Primary Liver Cancer (The Liver Cancer Study Group of Japan, 2009, 5th edition).