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Table 3 Clinicopathological characteristics and prognostic factors of 161 patients with OSCC measured by Apo10-/TKTL1-, Apo10+/TKTL1-, Apo10-/TKTL1+, and Apo10+/TKTL1+ expressors

From: A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells

Characteristics Number of Patients p-value
  Total Apo10-/TKTL1- Apo10+/TKTL1- Apo10-/TKTL1+ Apo10+/TKTL1+  
n = 161 n = 22 (14%) n = 71 (44%) n = 7 (4%) n = 61 (38%)
Age (y)       0.9067
<60 ± 11.8 80 (49.7%) 13 (16%) 32 (40%) 3 (4%) 32 (40%)  
≥60 ± 11.8 81 (50.3%) 9 (11%) 39 (48%) 4 (5%) 29 (36%)  
Gender       0.3179
Male 122 (75.8%) 18 (15%) 55 (45%) 5 (4%) 44 (36%)  
Female 39 (24.2%) 4 (10%) 16 (41%) 2 (5%) 17 (44%)  
Site distribution of OSCC       0.4899
Lips 11 (6.8%) 3 (27%) 6 (55%) 0 (0%) 2 (18%)  
Tongue 41 (25.5%) 5 (12%) 16 (39%) 3 (7%) 17 (42%)  
Floor of the mouth 64 (39.8%) 7 (11%) 30 (47%) 3 (5%) 24 (37%)  
Palate 15 (9.3%) 0 (0%) 6 (40%) 0 (0%) 9 (60%)  
Buccal mucosa 8 (5.0%) 3 (37.5%) 3 (37.5%) 0 (0%) 2 (25%)  
Alveolar ridge 22 (13.7%) 4 (18%) 10 (45%) 1 (5%) 7 (32%)  
Histological Grading       0.8621*
G1 41 (25.5%) 8 (19%) 15 (37%) 2 (5%) 16 (39%)  
G2 106 (65.8%) 10 (9%) 53 (50%) 5 (5%) 38 (36%)  
G3 13 (8.1%) 3 (23%) 3 (23%) 0 (0%) 7 (54%)  
G4 1 (0.6%) 1 (100%) 0 (0%) 0 (0%) 0 (0%)  
Tumor size       0.0002**
pT1 64 (39.8%) 14 (22%) 32 (50%) 0 (0%) 18 (28%)  
pT2 42 (26.1%) 8 (19%) 17 (41%) 3 (7%) 14 (33%)  
pT3 17 (10.6%) 0 (0%) 5 (29%) 0 (0%) 12 (71%)  
pT4 38 (23.6%) 0 (0%) 17 (45%) 4 (10%) 17 (45%)  
Cervical lymph node metastasis       0.0007
pN0 118 (73.3%) 19 (16%) 59 (50%) 4 (3%) 36 (31%)  
pN1-3 43 (26.7%) 3 (7%) 12 (28%) 3 (7%) 25 (58%)  
UICC stage       <0.0001***
UICC I 48 (29.8%) 12 (25%) 30 (63%) 0 (0%) 6 (12%)  
UICC II 36 (22.4%) 8 (22%) 15 (42%) 3 (8%) 10 (28%)  
UICC III 31 (19.3%) 1 (3%) 10 (32%) 0 (0%) 20 (65%)  
UICC IV 46 (28.6%) 1 (2%) 16 (35%) 4 (9%) 25 (54%)  
Locoregional recurrence       <0.0001
No 117 (72.7%) 21 (18%) 60 (51%) 6 (5%) 30 (26%)  
Yes 44 (27.3%) 1 (2%) 11 (25%) 1 (2%) 31 (71%)  
  1. Abbrevations: y years, G grading, UICC International Union against Cancer, *G1/2 vs. G3/4, **pT1/2 vs. pT3/4, ***UICC I/II vs. UICC III/IV.