Table 3 Previously published case-series in the literature of brain metastasis from HCC
From: Brain metastasis from hepatocellular carcinoma: the role of surgery as a prognostic factor
Author (year) | Patient number | Age (median) | Median interval between diagnosis of HCC and brain metastasis (months) | Median survival (weeks) | Treatment for brain metastasis | Survival time (weeks) | Positive prognostic factor |
|---|---|---|---|---|---|---|---|
Chang et al. (2004) | 45 | NA | 10.5 | 4 | Resection and/or radiotherapy | >16 | Single lesion |
Supportive care | <4 | ||||||
Choi et al. (2009) | 62 | 54 | 18.2 | 6.8 | Resection and WBRT | 33.6 | Single lesion, Child-Pugh’s classification A Any treatment modalities for brain metastasis |
Resection or WBRT or GKS | 10 | ||||||
Steroids alone | 2 | ||||||
Hsieh et al. (2009) | 42 | 55.8 | 15.4 | 4.8 | NA | NA | ICH did not influence |
Han et al. (2010) | 20 | 55 | 18.5 | 8 | Resection and WBRT | 8 | Younger age, Extracranial metastasis |
WBRT and/or GKS | 16 | ||||||
Jiang et al. (2012) | 41 | 48.5 | 15 | 12 | Resection or WBRT or GKS | 18 | No extracranial metastasis, Low RPA class, Any treatment modalities for brain metastasis |
Steroids alone | 10.8 | ||||||
Present Study (2013) | 33 | 62 | 18.3 | 10.4 | Resection/Resection+WBRT | 25.3 | No intratumoral bleeding Child-Pugh’s classification A, Resection for brain metastasis |
WBRT/GKS/WBRT+GKS | 10.4 | ||||||
Steroids alone | 1.0 |