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Table 3 Previously published case-series in the literature of brain metastasis from HCC

From: Brain metastasis from hepatocellular carcinoma: the role of surgery as a prognostic factor

Author (year) Patient number Age (median) Median interval between diagnosis of HCC and brain metastasis (months) Median survival (weeks) Treatment for brain metastasis Survival time (weeks) Positive prognostic factor
Chang et al. (2004) 45 NA 10.5 4 Resection and/or radiotherapy >16 Single lesion
Supportive care <4
Choi et al. (2009) 62 54 18.2 6.8 Resection and WBRT 33.6 Single lesion, Child-Pugh’s classification A Any treatment modalities for brain metastasis
Resection or WBRT or GKS 10
Steroids alone 2
Hsieh et al. (2009) 42 55.8 15.4 4.8 NA NA ICH did not influence
Han et al. (2010) 20 55 18.5 8 Resection and WBRT 8 Younger age, Extracranial metastasis
WBRT and/or GKS 16
Jiang et al. (2012) 41 48.5 15 12 Resection or WBRT or GKS 18 No extracranial metastasis, Low RPA class, Any treatment modalities for brain metastasis
Steroids alone 10.8
Present Study (2013) 33 62 18.3 10.4 Resection/Resection+WBRT 25.3 No intratumoral bleeding Child-Pugh’s classification A, Resection for brain metastasis
WBRT/GKS/WBRT+GKS 10.4
Steroids alone 1.0