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Table 4 Comparison of PIK3CA mutational status and alterations in other genes of interest

From: PIK3R1 underexpression is an independent prognostic marker in breast cancer

   Number of patients (%)  
Total population (%) PIK3CAwild-type PIK3CA-mutated P-value a
Total 458 (100.0) 307 (67.0) 151 (33.0)  
EGFR values: median [range] 0.2 (0.0-112.9) 0.2 (0.0-112.9) 0.2 (0.0-7.3)  
Underexpressed tumors (%) 389 (84.9) 256 (83.4) 133 (88.1) NS
Non-underexpressed tumors (%) 69 (15.1) 51 (16.6) 18 (11.9)
PIK3R1 values: median [range] 0.4 (0.0-5.2) 0.3 (0.0-4.4) 0.5 (0.1-5.2)  
Underexpressed tumors (%) 283 (61.8) 205 (66.8) 78 (51.7) 0.0017
Non-underexpressed tumors (%) 175 (38.2) 102 (33.2) 73 (48.3)
PDK1 values: median [range] 1.0 (0.0-14.7) 1.1 (0.0-14.7) 0.8 (0.1-4.5)  
Underexpressed tumors (%) 61 (13.3) 35 (11.4) 26 (17.2) 0.0011
Normally expressed tumors (%) 316 (69.0) 204 (66.5) 112 (74.2)
Overexpressed tumors (%) 81 (17.7) 68 (22.1) 13 (8.6)
PTEN values: median [range] 0.8 (0.1-9.0) 0.8 (0.1-5.8) 0.9 (0.1-9.0)  
Underexpressed tumors (%) 78 (17.0) 64 (20.8) 14 (9.3) 0.0019
Non-underexpressed tumors (%) 380 (83.0) 243 (79.2) 137 (90.7)
AKT1 values: median [range] 1.5 (0.0-11.1) 1.5 (0.0-11.1) 1.5 (0.4-9.9)  
Non-overexpressed tumors (%) 342 (74.7) 230 (74.9) 112 (74.2) NS
Overexpressed tumors (%) 116 (25.3) 77 (25.1) 39 (25.8)
AKT2 values: median [range] b 1.0 (0.7-2.3) 1.7 (0.5-12.2) 1.6 (0.5-10.6)  
Non-overexpressed tumors (%) 293 (64.3) 190 (62.3) 103 (68.2) NS
Overexpressed tumors (%) 163 (35.7) 115 (37.7) 48 (31.8)
AKT3 values: median [range] b 1.0 (0.4-1.9) 0.4 (0.0-3.6) 0.4 (0.1-7.5)  
Underexpressed tumors (%) 306 (67.1) 206 (67.5) 100 (66.2) NS
Non-underexpressed tumors (%) 150 (32.9) 99 (32.5) 51 (33.8)
GOLPH3 values: median [range] 1.4 (0.3-6.7) 1.4 (0.5-6.7) 1.3 (0.3-5.4)  
Non-overexpressed tumors (%) 369 (80.6) 242 (78.8) 127 (84.1) NS
Overexpressed tumors (%) 89 (19.4) 65 (21.2) 24 (15.9)
P70S6K values: median [range] 1.2 (0.0-19.6) 1.2 (0.0-19.6) 1.1 (0.4-8.0)  
Non-overexpressed tumors (%) 375 (81.9) 233 (75.9) 142 (94.0) 0.0000022
Overexpressed tumors (%) 83 (18.1) 74 (24.1) 9 (6.0)
WEE1 values: median [range] 0.8 (0.2-6.9) 0.8 (0.2-6.9) 0.7 (0.3-3.4)  
Underexpressed tumors (%) 84 (18.3) 61 (19.9) 23 (15.2) NS
Non-underexpressed tumors (%) 374 (81.7) 246 (80.1) 128 (84.8)
PIK3R1 c     
Wild-type (%) 444 (97.8) 294 (97.0) 150 (99.3) NS
Mutation (%) 10 (2.2) 9 (3.0) 1 (0.7)
AKT1 d     
Wild-type (%) 442 (96.7) 292 (95.4) 150 (99.3) NS
Mutation (%) 15 (3.3) 14 (4.6) 1 (0.7)
  1. aChi2 test. NS: not significant.
  2. bData available in 456 samples.
  3. cData available in 454 samples.
  4. dData available in 457 samples.
  5. The bold numbers stress important finding or overall characterisation of a group or p-value.