Table 4 Comparison of PIK3CA mutational status and alterations in other genes of interest
From: PIK3R1 underexpression is an independent prognostic marker in breast cancer
Number of patients (%) | ||||
|---|---|---|---|---|
Total population (%) | PIK3CAwild-type | PIK3CA-mutated | P-value a | |
Total | 458 (100.0) | 307 (67.0) | 151 (33.0) | |
EGFR values: median [range] | 0.2 (0.0-112.9) | 0.2 (0.0-112.9) | 0.2 (0.0-7.3) | |
Underexpressed tumors (%) | 389 (84.9) | 256 (83.4) | 133 (88.1) | NS |
Non-underexpressed tumors (%) | 69 (15.1) | 51 (16.6) | 18 (11.9) | |
PIK3R1 values: median [range] | 0.4 (0.0-5.2) | 0.3 (0.0-4.4) | 0.5 (0.1-5.2) | |
Underexpressed tumors (%) | 283 (61.8) | 205 (66.8) | 78 (51.7) | 0.0017 |
Non-underexpressed tumors (%) | 175 (38.2) | 102 (33.2) | 73 (48.3) | |
PDK1 values: median [range] | 1.0 (0.0-14.7) | 1.1 (0.0-14.7) | 0.8 (0.1-4.5) | |
Underexpressed tumors (%) | 61 (13.3) | 35 (11.4) | 26 (17.2) | 0.0011 |
Normally expressed tumors (%) | 316 (69.0) | 204 (66.5) | 112 (74.2) | |
Overexpressed tumors (%) | 81 (17.7) | 68 (22.1) | 13 (8.6) | |
PTEN values: median [range] | 0.8 (0.1-9.0) | 0.8 (0.1-5.8) | 0.9 (0.1-9.0) | |
Underexpressed tumors (%) | 78 (17.0) | 64 (20.8) | 14 (9.3) | 0.0019 |
Non-underexpressed tumors (%) | 380 (83.0) | 243 (79.2) | 137 (90.7) | |
AKT1 values: median [range] | 1.5 (0.0-11.1) | 1.5 (0.0-11.1) | 1.5 (0.4-9.9) | |
Non-overexpressed tumors (%) | 342 (74.7) | 230 (74.9) | 112 (74.2) | NS |
Overexpressed tumors (%) | 116 (25.3) | 77 (25.1) | 39 (25.8) | |
AKT2 values: median [range] b | 1.0 (0.7-2.3) | 1.7 (0.5-12.2) | 1.6 (0.5-10.6) | |
Non-overexpressed tumors (%) | 293 (64.3) | 190 (62.3) | 103 (68.2) | NS |
Overexpressed tumors (%) | 163 (35.7) | 115 (37.7) | 48 (31.8) | |
AKT3 values: median [range] b | 1.0 (0.4-1.9) | 0.4 (0.0-3.6) | 0.4 (0.1-7.5) | |
Underexpressed tumors (%) | 306 (67.1) | 206 (67.5) | 100 (66.2) | NS |
Non-underexpressed tumors (%) | 150 (32.9) | 99 (32.5) | 51 (33.8) | |
GOLPH3 values: median [range] | 1.4 (0.3-6.7) | 1.4 (0.5-6.7) | 1.3 (0.3-5.4) | |
Non-overexpressed tumors (%) | 369 (80.6) | 242 (78.8) | 127 (84.1) | NS |
Overexpressed tumors (%) | 89 (19.4) | 65 (21.2) | 24 (15.9) | |
P70S6K values: median [range] | 1.2 (0.0-19.6) | 1.2 (0.0-19.6) | 1.1 (0.4-8.0) | |
Non-overexpressed tumors (%) | 375 (81.9) | 233 (75.9) | 142 (94.0) | 0.0000022 |
Overexpressed tumors (%) | 83 (18.1) | 74 (24.1) | 9 (6.0) | |
WEE1 values: median [range] | 0.8 (0.2-6.9) | 0.8 (0.2-6.9) | 0.7 (0.3-3.4) | |
Underexpressed tumors (%) | 84 (18.3) | 61 (19.9) | 23 (15.2) | NS |
Non-underexpressed tumors (%) | 374 (81.7) | 246 (80.1) | 128 (84.8) | |
PIK3R1 c | ||||
Wild-type (%) | 444 (97.8) | 294 (97.0) | 150 (99.3) | NS |
Mutation (%) | 10 (2.2) | 9 (3.0) | 1 (0.7) | |
AKT1 d | ||||
Wild-type (%) | 442 (96.7) | 292 (95.4) | 150 (99.3) | NS |
Mutation (%) | 15 (3.3) | 14 (4.6) | 1 (0.7) | |