Table 2 Genes mRNA levels in the 4 breast tumor subtypes
From: PIK3R1 underexpression is an independent prognostic marker in breast cancer
All tumors | Tumor subtypes | |||||
|---|---|---|---|---|---|---|
HR-ERBB2- | HR-ERBB2+ | HR + ERBB2- | HR + ERBB2+ | P-value a | ||
n = 458 | n = 69 | n = 45 | n = 290 | n = 54 | ||
PIK3CA values: median [range] | 0.9 (0.2-33.4) | 0.9 (0.3-33.4) | 0.7 (0.3-1.7) | 0.9 (0.2-5.9) | 1.0 (0.4-5.6) | NS |
Underexpressed tumors (%) | 40 (8.7) | 6 (8.7) | 5 (11.1) | 25 (8.6) | 4 (7.4) | |
Non-underexpressed tumors (%) | 418 (91.3) | 63 (91.3) | 40 (88.9) | 265 (91.4) | 50 (92.6) | |
PIK3R1 values: median [range] | 0.4 (0.0-5.2) | 0.2 (0.0-2.2) | 0.3 (0.1-1.5) | 0.5 (0.1-4.4) | 0.4 (0.1-5.2) | <0.0000001 |
Underexpressed tumors (%) | 283 (61.8) | 61 (88.4) | 40 (88.9) | 150 (51.7) | 32 (59.3) | |
Non-underexpressed tumors (%) | 175 (38.2) | 8 (11.6) | 5 (11.1) | 140 (48.3) | 22 (40.7) | |
PDK1 values: median [range] | 1.0 (0.0-14.7) | 2.4 (0.5-14.7) | 1.7 (0.4-6.2) | 0.9 (0.0-3.3) | 0.9 (0.1-2.4) | <0.0000001 |
Underexpressed tumors (%) | 61 (13.3) | 0 | 1 (2.2) | 51 (7.9) | 9 (16.6) | |
Normally expressed tumors (%) | 316 (69.0) | 25 (36.2) | 27 (60.0) | 221 (90.0) | 43 (79.6) | |
Overexpressed tumors (%) | 81 (17.7) | 44 (63.8) | 17 (37.8) | 18 (2.1) | 2 (3.7) | |
PTEN values: median [range] | 0.8 (0.1-9.0) | 0.6 (0.1-1.5) | 0.8 (0.3-1.9) | 0.8 (0.1-9.0) | 0.9 (0.4-3.3) | 0.0000066 |
Underexpressed tumors (%) | 78 (17.0) | 27 (39.1) | 6 (13.3) | 39 (13.4) | 6 (11.1) | |
Non-underexpressed tumors (%) | 380 (83.0) | 42 (60.9) | 39 (86.7) | 251 (86.6) | 48 (88.9) | |
AKT1 values: median [range] | 1.5 (0.0-11.1) | 1.1 (0.0-11.1) | 2.0 (0.6-10.0) | 1.4 (0.4-6.1) | 1.8 (0.6-9.9) | 0.00019 |
Non-overexpressed tumors (%) | 342 (74.7) | 55 (79.7) | 24 (53.3) | 230 (79.3) | 33 (61.1) | |
Overexpressed tumors (%) | 116 (25.3) | 14 (20.3) | 21 (46.7) | 60 (20.7) | 21 (38.9) | |
AKT2 values: median [range] b | 1.7 (0.5-12.2) | 1.7 (0.7-12.2) | 1.4 (0.8-8.7) | 1.8 (0.5-10.6) | 1.8 (0.5-7.0) | 0.0097 |
Non-overexpressed tumors (%) | 293 (64.3) | 46 (67.6) | 38 (84.4) | 180 (62.3) | 29 (53.7) | |
Overexpressed tumors (%) | 163 (35.7) | 22 (32.4) | 7 (15.6) | 109 (37.7) | 25 (46.3) | |
AKT3 values: median [range] b | 0.4 (0.0-7.5) | 0.5 (0.0-2.2) | 0.3 (0.1-0.9) | 0.4 (0.0-7.5) | 0.4 (0.1-2.3) | NS |
Underexpressed tumors (%) | 306 (67.1) | 38 (55.9) | 32 (71.1) | 198 (68.5) | 38 (70.4) | |
Non-underexpressed tumors (%) | 150 (32.9) | 30 (44.1) | 13 (28.9) | 91 (31.5) | 16 (29.6) | |
GOLPH3 values: median [range] | 1.4 (0.3-6.7) | 1.2 (0.6-3.3) | 1.4 (0.7-5.0) | 1.3 (0.3-6.7) | 1.7 (0.8-5.4) | NS |
Non-overexpressed tumors (%) | 369 (80.6) | 54 (78.3) | 36 (80.0) | 241 (83.1) | 38 (70.4) | |
Overexpressed tumors (%) | 89 (19.4) | 15 (21.7) | 9 (20.0) | 49 (16.9) | 16 (29.6) | |
P70S6K values: median [range] | 1.2 (0.0-19.6) | 1.0 (0.0-5.4) | 1.9 (0.6-9.9) | 1.2 (0.3-8.0) | 1.4 (0.4-19.6) | <0.0000001 |
Non-overexpressed tumors (%) | 375 (81.9) | 64 (92.8) | 24 (53.3) | 250 (86.2) | 37 (68.5) | |
Overexpressed tumors (%) | 83 (18.1) | 5 (7.2) | 21 (46.7) | 40 (13.8) | 17 (31.5) | |
WEE1 values: median [range] | 0.8 (0.2-6.9) | 0.7 (0.2-6.9) | 0.9 (0.3-2.8) | 0.8 (0.2-3.9) | 0.8 (0.3-4.1) | 0.0014 |
Underexpressed tumors (%) | 84 (18.3) | 24 (34.8) | 6 (13.3) | 43 (14.8) | 11 (20.4) | |
Non-underexpressed tumors (%) | 374 (81.7) | 45 (65.2) | 39 (86.7) | 247 (85.2) | 43 (79.6) | |