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Table 2 Genes mRNA levels in the 4 breast tumor subtypes

From: PIK3R1 underexpression is an independent prognostic marker in breast cancer

  All tumors Tumor subtypes  
   HR-ERBB2- HR-ERBB2+ HR + ERBB2- HR + ERBB2+ P-value a
  n = 458 n = 69 n = 45 n = 290 n = 54  
PIK3CA values: median [range] 0.9 (0.2-33.4) 0.9 (0.3-33.4) 0.7 (0.3-1.7) 0.9 (0.2-5.9) 1.0 (0.4-5.6) NS
Underexpressed tumors (%) 40 (8.7) 6 (8.7) 5 (11.1) 25 (8.6) 4 (7.4)
Non-underexpressed tumors (%) 418 (91.3) 63 (91.3) 40 (88.9) 265 (91.4) 50 (92.6)
PIK3R1 values: median [range] 0.4 (0.0-5.2) 0.2 (0.0-2.2) 0.3 (0.1-1.5) 0.5 (0.1-4.4) 0.4 (0.1-5.2) <0.0000001
Underexpressed tumors (%) 283 (61.8) 61 (88.4) 40 (88.9) 150 (51.7) 32 (59.3)
Non-underexpressed tumors (%) 175 (38.2) 8 (11.6) 5 (11.1) 140 (48.3) 22 (40.7)
PDK1 values: median [range] 1.0 (0.0-14.7) 2.4 (0.5-14.7) 1.7 (0.4-6.2) 0.9 (0.0-3.3) 0.9 (0.1-2.4) <0.0000001
Underexpressed tumors (%) 61 (13.3) 0 1 (2.2) 51 (7.9) 9 (16.6)
Normally expressed tumors (%) 316 (69.0) 25 (36.2) 27 (60.0) 221 (90.0) 43 (79.6)
Overexpressed tumors (%) 81 (17.7) 44 (63.8) 17 (37.8) 18 (2.1) 2 (3.7)
PTEN values: median [range] 0.8 (0.1-9.0) 0.6 (0.1-1.5) 0.8 (0.3-1.9) 0.8 (0.1-9.0) 0.9 (0.4-3.3) 0.0000066
Underexpressed tumors (%) 78 (17.0) 27 (39.1) 6 (13.3) 39 (13.4) 6 (11.1)
Non-underexpressed tumors (%) 380 (83.0) 42 (60.9) 39 (86.7) 251 (86.6) 48 (88.9)
AKT1 values: median [range] 1.5 (0.0-11.1) 1.1 (0.0-11.1) 2.0 (0.6-10.0) 1.4 (0.4-6.1) 1.8 (0.6-9.9) 0.00019
Non-overexpressed tumors (%) 342 (74.7) 55 (79.7) 24 (53.3) 230 (79.3) 33 (61.1)
Overexpressed tumors (%) 116 (25.3) 14 (20.3) 21 (46.7) 60 (20.7) 21 (38.9)
AKT2 values: median [range] b 1.7 (0.5-12.2) 1.7 (0.7-12.2) 1.4 (0.8-8.7) 1.8 (0.5-10.6) 1.8 (0.5-7.0) 0.0097
Non-overexpressed tumors (%) 293 (64.3) 46 (67.6) 38 (84.4) 180 (62.3) 29 (53.7)
Overexpressed tumors (%) 163 (35.7) 22 (32.4) 7 (15.6) 109 (37.7) 25 (46.3)
AKT3 values: median [range] b 0.4 (0.0-7.5) 0.5 (0.0-2.2) 0.3 (0.1-0.9) 0.4 (0.0-7.5) 0.4 (0.1-2.3) NS
Underexpressed tumors (%) 306 (67.1) 38 (55.9) 32 (71.1) 198 (68.5) 38 (70.4)
Non-underexpressed tumors (%) 150 (32.9) 30 (44.1) 13 (28.9) 91 (31.5) 16 (29.6)
GOLPH3 values: median [range] 1.4 (0.3-6.7) 1.2 (0.6-3.3) 1.4 (0.7-5.0) 1.3 (0.3-6.7) 1.7 (0.8-5.4) NS
Non-overexpressed tumors (%) 369 (80.6) 54 (78.3) 36 (80.0) 241 (83.1) 38 (70.4)
Overexpressed tumors (%) 89 (19.4) 15 (21.7) 9 (20.0) 49 (16.9) 16 (29.6)
P70S6K values: median [range] 1.2 (0.0-19.6) 1.0 (0.0-5.4) 1.9 (0.6-9.9) 1.2 (0.3-8.0) 1.4 (0.4-19.6) <0.0000001
Non-overexpressed tumors (%) 375 (81.9) 64 (92.8) 24 (53.3) 250 (86.2) 37 (68.5)
Overexpressed tumors (%) 83 (18.1) 5 (7.2) 21 (46.7) 40 (13.8) 17 (31.5)
WEE1 values: median [range] 0.8 (0.2-6.9) 0.7 (0.2-6.9) 0.9 (0.3-2.8) 0.8 (0.2-3.9) 0.8 (0.3-4.1) 0.0014
Underexpressed tumors (%) 84 (18.3) 24 (34.8) 6 (13.3) 43 (14.8) 11 (20.4)
Non-underexpressed tumors (%) 374 (81.7) 45 (65.2) 39 (86.7) 247 (85.2) 43 (79.6)
  1. aChi2 test of independency in contingency tables (tumor subtype vs. gene expression). NS: not significant.
  2. bData available in 456 samples.
  3. The bold numbers stress important finding or overall characterisation of a group or p-value.