From: PIK3R1 underexpression is an independent prognostic marker in breast cancer
Genes | Median Ct of normal breast tissue (n = 10) | Normal breast tissue (n = 10) | Breast tumors n = 458 | Percentage of underexpressed tumors (Ntarget ≤0.5) | Percentage of normal expressed tumors | Percentage of overexpressed tumors (Ntarget ≥2) | Percentage of overexpressed tumors (Ntarget ≥5) |
---|---|---|---|---|---|---|---|
EGFR | 30.2 (29.3-31.5)a | 1.0 (0.7 -1.3)b | 0.2 (0.0-112.9)b | 84.9% c | 13.3% c | 1.8%c | 0.7%c |
PIK3CA | 29.7 (28.4-31.0) | 1.0 (0.7-1.3) | 0.9 (0.2-33.4) | 8.7% | 87.4% | 3.9% | 0.7% |
PIK3R1 | 26.8 (25.8-28.1) | 1.0 (0.7-1.5) | 0.4 (0.0-5.2) | 61.8% | 36.0% | 2.2% | 0.2% |
PDK1 | 31.8 (29.7-33.5) | 1.0 (0.5-1.9) | 1.0 (0.0-14.7) | 13.3% | 69.0% | 17.7% | 2.2% |
PTEN | 26.4 (25.3-31.3) | 1.1 (0.7-2.0) | 0.8 (0.1-9.0) | 17.0% | 81.0% | 2.0% | 0.4% |
AKT1 | 28.7 (27.5-30.1) | 1.0 (0.7-1.5) | 1.5 (0.0-11.1) | 1.3% | 73.4% | 25.3% | 2.8% |
AKT2 | 26.7 (25.4-29.7) | 1.0 (0.7-2.0) | 1.7 (0.5-12.2)d | 0.0% | 64.0% | 36.0% | 3.3% |
AKT3 | 26.0 (23.8-28.4) | 1.0 (0.6-1.9) | 0.4 (0.0-7.5)d | 67.1% | 31.1% | 1.8% | 0.2% |
GOLPH3 | 27.9 (26.4-29.0) | 1.0 (0.8-1.6) | 1.4 (0.3-6.7) | 0.7% | 79.9% | 19.4% | 0.9% |
P70S6K | 31.2 (29.9-32.7) | 1.0 (0.7-1.8) | 1.2 (0.0-19.6) | 2.2% | 79.7% | 18.1% | 3.7% |
WEE1 | 28.4 (26.1-29.8) | 1.0 (0.5-1.6) | 0.8 (0.2-6.9) | 18.3% | 77.3% | 4.4% | 0.2% |