PIK3R1 underexpression is an independent prognostic marker in breast cancer

BMC Cancer

Table 1 Gene mRNA levels in 458 breast tumors

Genes	Median Ct of normal breast tissue (n = 10)	Normal breast tissue (n = 10)	Breast tumors n = 458	Percentage of underexpressed tumors (Ntarget ≤0.5)	Percentage of normal expressed tumors	Percentage of overexpressed tumors (Ntarget ≥2)	Percentage of overexpressed tumors (Ntarget ≥5)
*EGFR*	30.2 (29.3-31.5)^a	1.0 (0.7 -1.3)^b	0.2 (0.0-112.9)^b	84.9% ^c	13.3% ^c	1.8%^c	0.7%^c
*PIK3CA*	29.7 (28.4-31.0)	1.0 (0.7-1.3)	0.9 (0.2-33.4)	8.7%	87.4%	3.9%	0.7%
*PIK3R1*	26.8 (25.8-28.1)	1.0 (0.7-1.5)	0.4 (0.0-5.2)	61.8%	36.0%	2.2%	0.2%
*PDK1*	31.8 (29.7-33.5)	1.0 (0.5-1.9)	1.0 (0.0-14.7)	13.3%	69.0%	17.7%	2.2%
*PTEN*	26.4 (25.3-31.3)	1.1 (0.7-2.0)	0.8 (0.1-9.0)	17.0%	81.0%	2.0%	0.4%
*AKT1*	28.7 (27.5-30.1)	1.0 (0.7-1.5)	1.5 (0.0-11.1)	1.3%	73.4%	25.3%	2.8%
*AKT2*	26.7 (25.4-29.7)	1.0 (0.7-2.0)	1.7 (0.5-12.2)^d	0.0%	64.0%	36.0%	3.3%
*AKT3*	26.0 (23.8-28.4)	1.0 (0.6-1.9)	0.4 (0.0-7.5)^d	67.1%	31.1%	1.8%	0.2%
*GOLPH3*	27.9 (26.4-29.0)	1.0 (0.8-1.6)	1.4 (0.3-6.7)	0.7%	79.9%	19.4%	0.9%
*P70S6K*	31.2 (29.9-32.7)	1.0 (0.7-1.8)	1.2 (0.0-19.6)	2.2%	79.7%	18.1%	3.7%
*WEE1*	28.4 (26.1-29.8)	1.0 (0.5-1.6)	0.8 (0.2-6.9)	18.3%	77.3%	4.4%	0.2%

^aMedian (range) of gene Ct values.
^bMedian (range) of gene mRNA levels; the mRNA values of the samples were normalized so that the median of the 10 normal breast tissue mRNA values was 1.
^cPercentages of underexpressing, normal and overexpressing tumors using cut-offs of Ntarget ≤0.5 and Ntarget ≥2.
^dData available in 456 samples.
The bold numbers stress important finding or overall characterisation of a group or p-value.

ISSN: 1471-2407