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Table 1 Gene mRNA levels in 458 breast tumors

From: PIK3R1 underexpression is an independent prognostic marker in breast cancer

Genes Median Ct of normal breast tissue (n = 10) Normal breast tissue (n = 10) Breast tumors n = 458 Percentage of underexpressed tumors (Ntarget ≤0.5) Percentage of normal expressed tumors Percentage of overexpressed tumors (Ntarget ≥2) Percentage of overexpressed tumors (Ntarget ≥5)
EGFR 30.2 (29.3-31.5)a 1.0 (0.7 -1.3)b 0.2 (0.0-112.9)b 84.9% c 13.3% c 1.8%c 0.7%c
PIK3CA 29.7 (28.4-31.0) 1.0 (0.7-1.3) 0.9 (0.2-33.4) 8.7% 87.4% 3.9% 0.7%
PIK3R1 26.8 (25.8-28.1) 1.0 (0.7-1.5) 0.4 (0.0-5.2) 61.8% 36.0% 2.2% 0.2%
PDK1 31.8 (29.7-33.5) 1.0 (0.5-1.9) 1.0 (0.0-14.7) 13.3% 69.0% 17.7% 2.2%
PTEN 26.4 (25.3-31.3) 1.1 (0.7-2.0) 0.8 (0.1-9.0) 17.0% 81.0% 2.0% 0.4%
AKT1 28.7 (27.5-30.1) 1.0 (0.7-1.5) 1.5 (0.0-11.1) 1.3% 73.4% 25.3% 2.8%
AKT2 26.7 (25.4-29.7) 1.0 (0.7-2.0) 1.7 (0.5-12.2)d 0.0% 64.0% 36.0% 3.3%
AKT3 26.0 (23.8-28.4) 1.0 (0.6-1.9) 0.4 (0.0-7.5)d 67.1% 31.1% 1.8% 0.2%
GOLPH3 27.9 (26.4-29.0) 1.0 (0.8-1.6) 1.4 (0.3-6.7) 0.7% 79.9% 19.4% 0.9%
P70S6K 31.2 (29.9-32.7) 1.0 (0.7-1.8) 1.2 (0.0-19.6) 2.2% 79.7% 18.1% 3.7%
WEE1 28.4 (26.1-29.8) 1.0 (0.5-1.6) 0.8 (0.2-6.9) 18.3% 77.3% 4.4% 0.2%
  1. aMedian (range) of gene Ct values.
  2. bMedian (range) of gene mRNA levels; the mRNA values of the samples were normalized so that the median of the 10 normal breast tissue mRNA values was 1.
  3. cPercentages of underexpressing, normal and overexpressing tumors using cut-offs of Ntarget ≤0.5 and Ntarget 2.
  4. dData available in 456 samples.
  5. The bold numbers stress important finding or overall characterisation of a group or p-value.