Table 1 Clinicopahtological characteristics of patients grouped according to GPS
Variable | GPS 0 (n = 81) | GPS 1 (n = 49) | GPS 2 (n = 20) | P-value |
|---|---|---|---|---|
Age (years) | 71 (43–91) | 74 (54–86) | 72 (51–79) | 0.05 |
Sex (male/female) | 57/23 | 33/16 | 16/4 | 0.57 |
HBsAg positive (%) | 8(10) | 4 (8.2) | 5 (25) | 0.12 |
HCVAb positive (%) | 52 (65) | 24 (49) | 7 (35) | 0.03 |
AST (IU/l) | 50 (18–148) | 58 (14–240) | 113 (13–384) | <0.0001 |
ALT (IU/l) | 39 (10–202) | 39 (12–190) | 78 (8–157) | 0.02 |
Total serum bilirubin (mg/dl) | 0.7 (0.3-1.9) | 1 (0.3-6.1) | 1.6 (0.3-8.3) | <0.0001 |
Albumin (g/dl) | 3.9 (3.5-5) | 3.2 (2.1-4.6) | 3.2 (2.2-3.4) | <0.0001 |
CRP (mg/dl) | 0.1 (0.1-0.8) | 0.3 (0.1-2.9) | 2.6 (1.1-18.8) | <0.0001 |
WBC (cells/mm3) | 5300 (2500–14800) | 5100 (1800–14900) | 5800 (3900–12400) | 0.13 |
Platelet count (104/mm3) | 14.2 (2.9-29.5) | 11.6 (1.8-42.1) | 17.3 (8.7-44.3) | 0.07 |
Prothrombin time (%) | 85 (38–100) | 78 (41–100) | 77 (45–97) | 0.02 |
α-fetoprotein (ng/ml) | 17 (1.9-59597) | 52 (2–138011) | 144 (1.7-280600) | 0.01 |
Child-Pugh grade (A/B/C) | 78/2/0 | 22/25/2 | 6/10/4 | <0.0001 |
CLIP score (0/1/2/3≧) | 35/31/10/4 | 8/12/17/12 | 0/7/1/12 | <0.0001 |
JIS score (0/1/2/3≧) | 17/32/27/4 | 0/15/17/17 | 0/1/6/13 | <0.0001 |
BCLC score (0/A/B/C,D) | 16/41/19/4 | 1/24/14/10 | 0/6/2/12 | <0.0001 |
Tumor stage (І,ІІ,ІІІ,ІV) | 16/34/28/2 | 4/22/16/7 | 1/4/4/11 | <0.0001 |
Maximal tumor diameter (mm) | 28 (7–90) | 37 (10–200) | 50 (10–130) | 0 |
Tumor number (solitary/multiple) | 45/35 | 26/23 | 5/15 | 0.04 |
Vascular invasion (absent/present) | 77/3 | 44/5 | 13/7 | 0 |
Extrahepatic metastasis (absent/present) | 79/1 | 47/2 | 17/3 | 0.02 |