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Table 3 Multivariate Cox proportional hazards regression analysis for overall survival and relapse-free survival

From: Expression of nerve growth factor and heme oxygenase-1 predict poor survival of breast carcinoma patients

Characteristics OS    RFS   
  HR 95% CI P HR 95% CI P
TNM stage,* I 1   0.002    
     II 3.542 1.241-10.109 0.018    
     III and IV 7.933 2.441-25.787 < 0.001    
HER2,* positive (vs. negative)     1.98 1.132-3.464 0.017
NGF,* positive (vs. negative) 2.174 1.073-4.404 0.031 3.042 1.746-5.299 < 0.001
HO1,* positive (vs. negative) 4.847 1.990-11.807 < 0.001    
NGF/HO1,** NGF-/HO1- 1   < 0.001 1   < 0.001
        NGF-/HO1+ 6.542 2.381-17.979 < 0.001 3.5 1.574-7.778 0.002
        NGF+/anyHO1 11.206 4.595-27.330 < 0.001 6.011 3.039-11.888 < 0.001
  1. * The variables included in the multivariate analysis were age, TNM stage, and the expression of HER2, NGF, and HO1. ** The variables included in the multivariate analysis were age, TNM stage, HER2 expression, and the combined expression pattern of NGF and HO1 (NGF/HO1).