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Table 3 Multivariate Cox proportional hazards regression analysis for overall survival and relapse-free survival

From: Expression of nerve growth factor and heme oxygenase-1 predict poor survival of breast carcinoma patients

Characteristics

OS

  

RFS

  
 

HR

95% CI

P

HR

95% CI

P

TNM stage,* I

1

 

0.002

   

     II

3.542

1.241-10.109

0.018

   

     III and IV

7.933

2.441-25.787

< 0.001

   

HER2,* positive (vs. negative)

   

1.98

1.132-3.464

0.017

NGF,* positive (vs. negative)

2.174

1.073-4.404

0.031

3.042

1.746-5.299

< 0.001

HO1,* positive (vs. negative)

4.847

1.990-11.807

< 0.001

   

NGF/HO1,** NGF-/HO1-

1

 

< 0.001

1

 

< 0.001

        NGF-/HO1+

6.542

2.381-17.979

< 0.001

3.5

1.574-7.778

0.002

        NGF+/anyHO1

11.206

4.595-27.330

< 0.001

6.011

3.039-11.888

< 0.001

  1. * The variables included in the multivariate analysis were age, TNM stage, and the expression of HER2, NGF, and HO1. ** The variables included in the multivariate analysis were age, TNM stage, HER2 expression, and the combined expression pattern of NGF and HO1 (NGF/HO1).
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BMC Cancer

ISSN: 1471-2407

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