Optical imaging of tumor vascularity associated with proliferation and glucose metabolism in early breast cancer: clinical application of total hemoglobin measurements in the breast

Table 2 Clinicopathological factor and biomarker results in hotspot versus uniform-patterned breast cancers assigned by tHb optical imaging

Variables	Values	Total	Hotspot	Uniform	p value
Age	Mean(year) ± SD	58.6 ± 12.3	59.9 ± 11.7	56.5 ± 13	NS ^*
TNM Stage	I	25	9	16	p = 0.01 ^†
TNM Stage	II	30	22	8	p = 0.01 ^†
Tumor size	Mean(mm) ± SD	21.5 ± 9	24.8 ± 9.9	17.4 ± 5.6	p = 0.002 ^*
Nuclear atypia	High	37	20	17	NS ^**
Nuclear atypia	Low	5	3	2	NS ^**
Mitosis	High	14	12	2	p = 0.01 ^**
Mitosis	Low	28	11	17	p = 0.01 ^**
Nodal status	Positive	10	4	6	NS ^**
Nodal status	Negative	33	20	13	NS ^**
ER	Positive	45	24	21	NS ^**
ER	Negative	6	5	1	NS ^**
PgR	Positive	41	21	20	NS ^**
PgR	Negative	10	8	2	NS ^**
HER2	Positive	6	4	2	NS ^**
HER2	Negative	44	24	20	NS ^**
FDG SUVmax	Mean ± SD	5 ± 3.3	6.6 ± 3.2	2.6 ± 1.7	p = 0.0004 ^*

SD, standard deviation; NS, not statistically significant; ^*Student’s t test; ^**Fisher’s exact test, ^†Pearson’s chi square.

ISSN: 1471-2407