Table 1 Characteristics of DCIS by surrogate molecular subtypes according to the St Gallen international expert consensus 2011 (n=458)
Ductal carcinoma in situ characteristics | All | Luminal A | Luminal B/HER2- | Luminal B/HER2+ | HER2+/ER- | Triple negative | Unclassified | P valueb | P valuec |
|---|---|---|---|---|---|---|---|---|---|
n=458 | n=186, (%) | n=33, (%) | n=74, (%) | n=61, (%) | n=27, (%) | n=77, (%) | |||
Percentage of all | n=458 | (40.6) | (7.2) | (16.2) | (13.3) | (5.9) | (16.8) | ||
Percentage of all classified | n=381 | (48.8) | (8.7) | (19.4) | (16.0) | (7.1) | - | ||
Age mean, years | 58.2 | 59.6 | 55.2 | 55.2 | 58.4 | 59.2 | 58.2 | ||
< 50 | 121(26.4) | 48 (25.8) | 12 (36.4) | 23 (31.1) | 14 (23.0) | 8 (29.6) | 16 (20.8) | 0.38 | 0.42 |
50- 65 | 198 (43.2) | 77 (41.4) | 14 (42.4) | 33 (44.6) | 30 (49.2) | 7 (25.9) | 37 (48.0) | ||
> 65 | 139 (30.3) | 61 (32.8) | 7 (21.2) | 18 (24.3) | 17 (27.9) | 12 (44.4) | 24 (31.2) | ||
Detection mode | |||||||||
Screening | 345 (75.5) | 134 (72.0) | 27 (81.8) | 67 (90.5) | 44 (72.1) | 18 (66.7) | 55 (71.4) | 0.10 | 0.16 |
Clinically | 112 (24.5) | 51 (27.4) | 6 (18.2) | 7 (9.5) | 17 (27.9) | 9 (33.3) | 22 (28.6) | ||
Tumor size | |||||||||
Unifocal, mean, mm | 16.7 | 14.9 | 16.5 | 16.4 | 21.8 | 19.9 | 16.3 | 0.93d | 0.91d |
Multifocal (number) | n=54 | n=22 | n=3 | n=11 | n=8 | n=3 | n=7 | ||
Histopathological grade a | |||||||||
Grade 1 | 37 (8.1) | 23 (12.4) | 1 (3.0) | 1 (1.4) | 1 (1.6) | 1 (3.7) | 10 (13.0) | <0.01 | <0.01 |
Grade 2 | 203 (44.6) | 121 (65.0) | 17 (51.5) | 20 (27.0) | 6 (9.8) | 9 (33.3) | 32 (41.6) | ||
Grade 3 | 215 (47.3) | 42 (22.6) | 15 (45.5) | 53 (71.6) | 54 (88.5) | 17 (63.0) | 35 (44.4) | ||
Type of surgery | |||||||||
Breast Conserving Surgery | 359 (78.4) | 151 (81.2) | 28 (84.8) | 57 (77.0) | 41 (67.2) | 22 (81.5) | 60 (77.9) | 0.17 | 0.27 |
Mastectomy | 99 (21.6) | 35 (18.8) | 5 (15.2) | 17 (23.0) | 20 (32.8) | 5 (18.5) | 17 (22.1) | ||
Postoperative radiotherapy | |||||||||
Yes | 161 (35.2) | 63 (33.9) | 17 (51.5) | 27 (36.5) | 23 (37.7) | 9 (33.3) | 22 (28.6) | 0.42 | 0.33 |
No | 297 (64.8) | 123 (66.1) | 16 (48.5) | 47 (63.5) | 38 (62.3) | 18 (66.7) | 55 (71.4) |