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Table 1 Characteristics of DCIS by surrogate molecular subtypes according to the St Gallen international expert consensus 2011 (n=458)

From: Molecular subtypes in ductal carcinoma in situ of the breast and their relation to prognosis: a population-based cohort study

Ductal carcinoma in situ characteristics All Luminal A Luminal B/HER2- Luminal B/HER2+ HER2+/ER- Triple negative Unclassified P valueb P valuec
  n=458 n=186, (%) n=33, (%) n=74, (%) n=61, (%) n=27, (%) n=77, (%)   
Percentage of all n=458 (40.6) (7.2) (16.2) (13.3) (5.9) (16.8)   
Percentage of all classified n=381 (48.8) (8.7) (19.4) (16.0) (7.1) -   
Age mean, years 58.2 59.6 55.2 55.2 58.4 59.2 58.2   
< 50 121(26.4) 48 (25.8) 12 (36.4) 23 (31.1) 14 (23.0) 8 (29.6) 16 (20.8) 0.38 0.42
50- 65 198 (43.2) 77 (41.4) 14 (42.4) 33 (44.6) 30 (49.2) 7 (25.9) 37 (48.0)   
> 65 139 (30.3) 61 (32.8) 7 (21.2) 18 (24.3) 17 (27.9) 12 (44.4) 24 (31.2)   
Detection mode          
Screening 345 (75.5) 134 (72.0) 27 (81.8) 67 (90.5) 44 (72.1) 18 (66.7) 55 (71.4) 0.10 0.16
Clinically 112 (24.5) 51 (27.4) 6 (18.2) 7 (9.5) 17 (27.9) 9 (33.3) 22 (28.6)   
Tumor size          
Unifocal, mean, mm 16.7 14.9 16.5 16.4 21.8 19.9 16.3 0.93d 0.91d
Multifocal (number) n=54 n=22 n=3 n=11 n=8 n=3 n=7   
Histopathological grade a          
Grade 1 37 (8.1) 23 (12.4) 1 (3.0) 1 (1.4) 1 (1.6) 1 (3.7) 10 (13.0) <0.01 <0.01
Grade 2 203 (44.6) 121 (65.0) 17 (51.5) 20 (27.0) 6 (9.8) 9 (33.3) 32 (41.6)   
Grade 3 215 (47.3) 42 (22.6) 15 (45.5) 53 (71.6) 54 (88.5) 17 (63.0) 35 (44.4)   
Type of surgery          
Breast Conserving Surgery 359 (78.4) 151 (81.2) 28 (84.8) 57 (77.0) 41 (67.2) 22 (81.5) 60 (77.9) 0.17 0.27
Mastectomy 99 (21.6) 35 (18.8) 5 (15.2) 17 (23.0) 20 (32.8) 5 (18.5) 17 (22.1)   
Postoperative radiotherapy          
Yes 161 (35.2) 63 (33.9) 17 (51.5) 27 (36.5) 23 (37.7) 9 (33.3) 22 (28.6) 0.42 0.33
No 297 (64.8) 123 (66.1) 16 (48.5) 47 (63.5) 38 (62.3) 18 (66.7) 55 (71.4)   
  1. aDCIS were classified according to the European Organization for Research and Treatment of Cancer (EORTC) system.
  2. bP-values were calculated between molecular subgroups by IHC, unclassified lesions were excluded.
  3. cP-values were calculated between molecular subgroups by IHC, unclassified lesions were included.
  4. dChi-square test of categorical size groups (unifocal vs. multifocal).