Figure 4
In vivo anti-tumor effect of LAT inhibition on cholangiocarcinoma xenograft. (A) Intravenous administration of BCH shows delay in the growth of HuCCT1 tumor (n = 10). A statistically significant difference from the control is indicated by * (P < 0.05), ** (P < 0.01), and *** (P < 0.001). (B) Changes in the body weight of HuCCT1 tumor-bearing mice after administration of BCH (n = 10). (C) Representative coronal section of 18F-FDG PET images of HuCCT1-bearing mice at 2 h after 18F-FDG injection. PET imaging was performed at indicated day after the day of grouping (n = 2). The calibration bar is shown at right-side of images. SUV max and SUV 50% are shown below the images.