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Table 6 Association of body size with premenopausal breast cancer by hormone receptor status

From: Body fatness and breast cancer risk in women of African ancestry

  

ER+/PR+ vs. controls

ER-/PR- vs. controls

ER-/PR- cases vs. ER+/PR+ cases

 

CO

CA

OR

95% CI

CA

OR

95% CI

OR

95% CI

Current BMI*

         

  Underweight/Normal (<25)

103

42

Ref

 

20

Ref

 

Ref

 

 Overweight (25–29.99)

142

58

1.15

0.67–1.96

31

1.17

0.59–2.34

1.05

0.47–2.37

 Obese (≥30)

237

95

1.34

0.68–2.68

51

1.26

0.53–3.00

0.88

0.30–2.54

  p for trend

   

0.40

  

0.65

 

0.74

% Body fat

         

 ≤35.9

137

62

Ref

 

20

Ref

 

Ref

 

 36–41.6

118

51

0.99

0.59–1.64

26

1.20

0.61–2.34

1.23

0.58–2.64

 41.7–46.5

104

43

1.10

0.59–2.05

21

1.28

0.58–2.86

1.17

0.47–2.92

 >46.5

106

30

0.91

0.37–2.24

24

1.78

0.59–5.37

1.68

0.47–6.08

  p for trend

   

0.96

  

0.36

 

0.52

Waist to hip ratio

         

 ≤0.82

144

56

Ref

 

20

Ref

 

Ref

 

 0.83–0.87

120

48

0.99

0.60–1.63

27

1.13

0.61–2.10

1.20

0.58–2.49

 0.88–0.92

121

45

1.06

0.63–1.78

23

1.02

0.52–2.00

0.97

0.44–2.15

 >0.92

93

43

1.33

0.76–2.32

24

1.51

0.74–3.05

1.30

0.57–3.00

  p for trend

   

0.33

  

0.32

 

0.63

Waist circumference (cm)

         

 ≤87.88

143

57

Ref

 

20

Ref

 

Ref

 

 87.89–97.75

119

52

1.28

0.76–2.17

24

1.07

0.55–2.10

0.80

0.37–1.75

 97.76–110.25

116

47

1.57

0.80–3.08

25

1.52

0.67–3.47

0.78

0.28–2.16

 >110.25

100

36

2.05

0.79–5.35

23

1.91

0.59–6.13

0.73

0.17–3.08

  p for trend

   

0.13

  

0.25

 

0.67

Hip circumference (cm)

         

 ≤103.18

138

55

Ref

 

20

Ref

 

Ref

 

 103.19–111.63

111

52

1.50

0.89–2.54

33

2.25

1.16–4.37

1.36

0.61–3.00

 111.64–123.15

116

40

1.69

0.89–3.20

22

1.65

0.73–3.73

0.75

0.28–1.99

 >123.15

113

46

3.59

1.43–9.03

24

2.60

0.79–8.54

0.47

0.12–1.95

  p for trend

   

0.01

  

0.22

 

0.15

  1. *BMI measured at interview.
  2. Abbreviations: CO number of controls, CA number of cases, ER estrogen receptor, PR progesterone receptor.
  3. Adjusted for age, ethnicity, country of origin (United States, Caribbean, other), education, family history of breast cancer, history of benign breast disease, age at menarche, parity (continuous), breastfeeding (yes/no), age at first birth, HRT use (ever/never), OC use (ever/never). BMI also adjusted for waist circumference. Percent body fat, waist circumference, and hip circumference, also adjusted for BMI.
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BMC Cancer

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