Figure 5

Nuclear STAT3 in stage II colon cancer is associated with negative pathological features. (A) Representative examples of immunohistochemical staining for STAT3 showing strongly positive (3+) and negative levels. Bar is 100 micron. (B) Nuclear STAT3 is associated with higher grade tumors, where fewer than 5% of high grade tumors received a negative staining score compared to nearly 22% of low grade tumors (p < 0.0266). (C) Nuclear STAT3 is associated with lymphovascular invasion. No patients with LVI had negative nuclear STAT3 staining (p < 0.0218). (D) High levels of cytoplasmic STAT3 are associated with tumor grade, with higher levels correlating with higher grade (p = 0.03).