Genetic variations of E6 and long control region of human papillomavirus type 16 from patients with cervical lesion in Liaoning, China

Table 3 Variations of HPV 16 LCR in strains from patients with different grades of cervical lesions

Nucleotide variations	Transcription factors	No. of women with cervical different grades of cervical lesions dysplasia
Nucleotide variations	Transcription factors	Normal n=95	CIN1/LSIL n=42	CIN2–3 n=117	CC n=50	Total n=304
^N G7193T	SRY	95	42	117	50	304
T7201C	SRY	65	8	17	16	106
T7228A	CdxA	17	4	0	8	29
A7238C	CdxA	25	4	8	0	37
T7238A	RAP1	17	4	0	8	29
C7270T	USF	65	8	17	16	106
A7279T	USF	0	5	8	4	17
A7287C		65	8	17	16	106
A7289C		51	8	13	8	80
^N C7294T	CdxA	0	4	8	10	22
^N G7319A		0	4	8	10	22
^N A7326G		0	4	8	10	22
A7339T	SRY	12	4	0	8	24
^N T7350A	Dfd, S8	0	4	8	10	22
^N T7368G	CF2-II	0	4	8	10	22
^N 7434C(Ins)		95	42	117	50	304
C7436T	E2	95	42	117	50	304
G7447T		12	4	0	8	24
G7456A		12	4	0	8	24
G7502T	CdxA	17	4	4	8	33
^N T7503G	HSF	0	4	8	10	22
^N A7515C	AP-1,cap	0	4	8	10	22
G7521A		95	42	117	50	304
^N G7553T	Sox-5, SRY,HFH-2	0	4	8	10	22
^N A7602G	P	0	4	8	10	22
T7608C	Hb	8	0	4	4	16
G7677A	E2F	12	4	0	8	24
G7683A	E2F	12	4	0	8	24
T7714G		19	7	2	2	30
A7730C	Oct-1	65	8	17	16	106
^N A7740T	Oct-1	0	4	8	10	22
T7755A		12	4	0	8	24
T7781C	cap	25	0	17	0	42
T7841A		12	4	0	0	16
G7842A		65	8	17	16	106
^N 7863A(Del)		95	42	117	50	304
G7868A		28	0	9	4	34
T7880C	CdxA	12	4	0	8	24
A7884C		12	4	0	8	24
G7885A		12	4	0	8	24
C7930T	SRY	65	8	17	16	106

Note: HPV 16 prototype (GenBank accession number KO 2718) was used as the reference. Nucleotide positions in LCR are presented according to the reference sequence. Novel variations are labeled as 'N’.

ISSN: 1471-2407