Table 2 Variations of HPV 16 E6 gene in strains from patients with different grades of cervical lesions
Variation of HPV-16 E6 at nucleotide position (450bp) | Grade of Related Cervical lesion | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Categories | 94 | 131 | 176 | 178 | 215 | 241 | 335 | 350 | 442 | Normal n =95 | CIN1/LSIL n =42 | CIN2-3 n =117 | CC n =50 | Total n=304 |
KO2718 | G | A | G | T | C | T | C | T | A | |||||
Variation | A | C/G | A | A/G | T | G | T | G | C | |||||
EUR | _ | _ | _ | _ | _ | _ | _ | _ | _ | 10 | 5 | 4 | 5 | 24 |
EUR | a | _ | _ | _ | _ | _ | _ | _ | _ | 10 | 2 | 18 | 0 | 30 |
EUR | _ | _ | _ | _ | t | _ | _ | _ | _ | 10 | 2 | 0 | 0 | 12 |
EUR | _ | _ | _ | _ | _ | g | _ | _ | _ | 6 | 10 | 2 | 4 | 22 |
EUR | _ | _ | a | _ | _ | _ | _ | _ | _ | 12 | 4 | 1 | 0 | 17 |
EUR | _ | _ | _ | _ | _ | _ | _ | _ | C | 5 | 0 | 0 | 0 | 5 |
EUR | _ | _ | _ | _ | _ | _ | T | _ | _ | 11 | 2 | 0 | 0 | 13 |
EUR | _ | _ | _ | A | _ | _ | _ | _ | _ | 7 | 4 | 17 | 10 | 38 |
EUR | a | _ | _ | _ | _ | _ | _ | G | _ | 4 | 0 | 0 | 0 | 4 |
EUR | a | _ | _ | _ | _ | _ | _ | G | C | 3 | 0 | 0 | 0 | 3 |
EUR | _ | G | _ | _ | _ | _ | _ | G | _ | 0 | 1 | 8 | 0 | 9 |
EUR | _ | _ | _ | _ | _ | _ | _ | G | _ | 3 | 2 | 9 | 0 | 14 |
As | _ | c | _ | G | _ | _ | _ | _ | _ | 6 | 3 | 4 | 19 | 32 |
As | _ | _ | _ | G | _ | _ | _ | _ | _ | 8 | 7 | 54 | 12 | 81 |
AminoAcid substitution | _ | R10G | _ | D25E | _ | _ | H78Y | L83V | E113D | Â | Â | Â | Â | Â |