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Table 5 Multivariate survival analysis - categorical methylation data

From: Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors

Covariate Baseline Coefficient(bi) HR(exp(bi) p-value 95,0%CI for Exp(B)
TP53 TP53 wild type −2.332 0.097 6.6e-5 (0.030-0.305)
ER ER positive 1.481 4.401 0.008 (1.460-13.269)
Stage II Stage I 2.260 9.584 0.013 (1.593-57.667)
Stage III Stage I −0.011 0.988 0.992 (0.088-11.019)
N1 N0 −6.362 0.529 0.338 (0.143-1.947)
N2 N0 1.673 5.332 0.047 (1.019-27.885)
IGF2 Normal like IGF2 1.597 4.940 0.009 (1.472-16.581)
GSTP1 Normal like GSTP1 −1.621 0.197 0.014 (0.053-0.729)
PPP2R2B Normal like PPP2R2B −0.972 0.378 0.085 (0.125-1.143)
CDKN2A Normal like CDKN2A −0.839 0.432 0.133 (0.144-1.294)
  1. The variables that the minimum AIC selected. ( p-values: 3.4e-7 for likelihood ratio test, 3.4e-4 for Wald test, 3.2e-6 for log-rank test).
  2. Positive hazard ratios indicate an increased risk of dying from breast cancer and are calculated for the different covariates.