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Table 4 Associations between methylation status and TP53 mutation and hormone receptor status

From: Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors

GENE

TP53 wt/mut p-value

ER pos/neg p-value

HER2 pos/neg p-value

 

WT% meth

Mut% meth

p-value

  

BRCA1

87.34

79.99

0.001

  

PTEN

5.34

4.67

0.031

 

3.6e-6

PPP2R2B

11.33

9.47

0.002

0.012

 

FOXC1

17.12

13.56

0.017

0.032

 

ABCB1

14.52

10.28

0.010

  

RASSF1A

32.48

26.58

0.028

0.004

0.023

GSTP1

   

0.012

 

CDKN2A

    

5.8e-9

MGMT

    

1.1e-7

ESR1

    

0.017

  1. Indicated are % methylation within the studied subgroups together with p-values for differences in DNA methylation levels between genes in connection with ER, HER2 and TP53 mutation status. Mann–Whitney test.
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BMC Cancer

ISSN: 1471-2407

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