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Table 4 Associations between methylation status and TP53 mutation and hormone receptor status

From: Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors

GENE TP53 wt/mut p-value ER pos/neg p-value HER2 pos/neg p-value
  WT% meth Mut% meth p-value   
BRCA1 87.34 79.99 0.001   
PTEN 5.34 4.67 0.031   3.6e-6
PPP2R2B 11.33 9.47 0.002 0.012  
FOXC1 17.12 13.56 0.017 0.032  
ABCB1 14.52 10.28 0.010   
RASSF1A 32.48 26.58 0.028 0.004 0.023
GSTP1     0.012  
CDKN2A      5.8e-9
MGMT      1.1e-7
ESR1      0.017
  1. Indicated are % methylation within the studied subgroups together with p-values for differences in DNA methylation levels between genes in connection with ER, HER2 and TP53 mutation status. Mann–Whitney test.