Impacts of clinicopathologic and operative factors on short-term and long-term survival in renal cell carcinoma with venous tumor thrombus extension: a multi-institutional retrospective study in Japan

Table 5 Multivariate Cox proportional hazards model on predictors of overall survival in all participants and yearly-based survivors diagnosed with renal cell carcinoma extending into renal vein or inferior vena cava

Variables	Estimate	±	Standard error	Hazard ratio		p value
Variables	Estimate	±	Standard error	(95% Confident interval)		p value
All cases
Renal vein/ inferior vena cava wall invasion status	0.80	±	0.30	2.22	(1.22-4.02)	0.00876
Pathological subtype	0.45	±	0.24	1.57	(0.97-2.53)	0.06486
Surgical category	0.55	±	0.16	1.73	(1.25-2.39)	0.00088
Survivors at 1 year of follow-up
IAP	2.62	±	0.50	13.68	(5.16-36.3)	0.00000
Pathological subtype	0.53	±	0.21	1.70	(1.11-2.59)	0.01371
Survivors at 2 years of follow-up
Renal vein/ inferior vena cava wall invasion status	1.15	±	0.44	3.16	(1.35-7.44)	0.00825
PS	0.91	±	0.47	2.49	(1.00-6.25)	0.05122
Survivors at 3 years of follow-up
Renal vein/ inferior vena cava wall invasion status	1.60	±	0.48	4.96	(1.93-12.8)	0.00090
PS	0.89	±	0.50	2.43	(0.91-6.44)	0.07531

In the stepwise multiple regression analysis, 232-712 μg/ml IAP, 0 PS, radical nephrectomy and complete resection of thrombus without metastasis in surgical category, non-venous wall-invasive thrombus in renal vein/ inferior vena cava wall invasion, and clear cell subtype on pathological subtype are coded as 1.
Similarly, 713–2048 μg/ml IAP, 1–4 PS, radical nephrectomy and complete resection of thrombus with metastases that has undergone a cytoreductive surgery in surgical category, venous wall-invasive thrombus in renal vein/ inferior vena cava wall invasion, and papillary/chromophobe//others excluding spindle or sarcoma subtype in pathological subtype are coded as 2.
Spindle or sarcomatoid pathological subtype, radical nephrectomy and complete resection of thrombus with unresected metastases in surgical category are coded as 3.
Radical nephrectomy and incomplete resection of thrombus regardless of metastatic status in surgical category is coded as 4.
Abandoned operation in surgical category is coded as 5.

ISSN: 1471-2407