Report | Study design | Site | Stage and number of patients | Exclusions | Haematology measured | Pre-op RT or RT/CT | Adjuvant CT | Minimum follow-up time of surviving patients | NLR variable | NLR Significant in bivariate analysis | NLR Significant in multivariate analysis |
---|---|---|---|---|---|---|---|---|---|---|---|
Walsh 2005 [7] | Retrospective | Colorectal | A: 30 | None specified | For stages A-D: | 3 patients | Not | 24 months | Binary | OS: yes | OS: no |
B: 80 |  | specified | < 5 vs. ≥ 5 | CSS: yes | CSS: no | ||||||
C: 65 | Pre-op | ||||||||||
D: 26 | For unresected: | ||||||||||
unresected | Â | ||||||||||
29 | during diagnosis | ||||||||||
Total 230 | |||||||||||
Leitch 2007 [10] | Retrospective | Colorectal | I: 22 | Infection or | Not specified | 11 | Not | 36 months | Binary | Stages I-III | Stages I-III |
II: 62 | inflammatory | patients | specified | < 5 vs. ≥ 5 | OS: no | OS: no | |||||
III: 65 | conditions | CSS: no | CSS: no | ||||||||
IV: (liver mets) 84 | Stage IV | Stage IV | |||||||||
 | OS: no | OS: no | |||||||||
Total 233 | CSS: no | CSS: no | |||||||||
Ding 2010 [12] | Retrospective | Colon | IIA: 141 | Adjuvant | < 1 week | Not | Not | Not | Binary | RFS: yes | RFS: yes |
CT | before | specified | specified | specified | ≤ 4 vs. > 4 |  | |||||
Multiple | resection | The precise | |||||||||
primaries, | definition | ||||||||||
polypolsis, | of RFS in | ||||||||||
HNPCC, | respect of | ||||||||||
infection or | censoring | ||||||||||
haematological | is not | ||||||||||
disorders | specified | ||||||||||
Liu 2010 [5] | Retrospective | Rectum | I: 17 | Synchronous or | Not specified | Not | All stage | Not | Binary | CSS: no | CSS: yes |
II: 59 | metachronous | specified | III or IV | specified | <2 vs. >2 | ||||||
III+IV: 47 | cancer. | Not | |||||||||
Total 123 | Lost to follow | specified | |||||||||
up | when | ||||||||||
exactly 2 | |||||||||||
Hung 2011 [9] | Retrospective | Colon | II: 1040 | Adjuvant | Before | Not | Excluded | 46 months | Binary | OS: yes | OS: yes |
based on | CT | resection | specified | <5 vs. ≥5 | DFS: yes | DFS: yes | |||||
tumor | DFS not | ||||||||||
registry | precisely | ||||||||||
data | defined | ||||||||||
Kwon 2012 [4] | Retrospective | Colorectal | I: 13 | Emergency | 1 day before | Not | 150 | Not | Binary | OS: yes | OS: no |
II: 91 | Surgery. | resection | specified | patients | specified | < 5 vs. ≥ 5 | After | ||||
III: 88 | Death < 30 | adjusting for | |||||||||
IV: 8 | days after | platelet/ | |||||||||
Total: 200 | surgery. | lymphocyte | |||||||||
Infection or | ratio | ||||||||||
inflammatory | |||||||||||
conditions | |||||||||||
Chiang 2012 [11] | Retrospective | Colorectal | Curative | Anal cancer. | Pre-op | 124 | 73 | 11.6 | Binary | DFS: yes | DFS: yes |
only | Primary site | undefined | patients | patients | months | ≤3 vs. >3 |  | ||||
undefined. | indefinite. | Â | DFS not | ||||||||
Composite | Synchronous | not | precisely | ||||||||
TNM | colon & rectum. | excluded | defined | ||||||||
stage not | |||||||||||
given; | Complicated | ||||||||||
Total | presentations. | ||||||||||
patients in | |||||||||||
NLR survival | |||||||||||
analyses = 3177 | |||||||||||
Mallappa 2013 [6] | Retrospective | Colorectal | 297 patients. | Inflammatory or | Pre-op | excluded | Not | Not | Binary | DFS: yes | DFS: yes |
 | haematological | undefined | specified | specified | < 5 vs. >5 | ||||||
Jass stage: | disorders. | DFS not | |||||||||
1: 90 | Pre-op RT | Not | precisely | ||||||||
2: 71 | Emergency | specified | defined | ||||||||
3: 58 | resection. | when | |||||||||
4: 78 | Non-curative. | exactly 5 | |||||||||
Died ≤ 30 days | |||||||||||
 |  |  |  | postoperatively. |  |  |  |  |  |  |  |