Table 4 Mean IC 50 values of drugs grouped according to histopathological categories and previous treatment in the CRC subgroup
Drugs | Prior Chemotherapy | Lymph node | Mucinous | Tumour differentiation | Signet cell | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
n=49† | Yes | No | Pos | Neg | Yes | No | Poor | Moderate | Well | Yes | No |
n=39 | n=10 | n=37 | n=12 | n=29 | n=20 | n=19 | n=24 | n=6 | n=6 | n=43 | |
Oxa | 31.7 | 30.1 (0.9) | 31.0 | 32.4 (0.9) | 36.9 | 22.6 (0.1) | 34.7 | 23.9 (0.5) | 35.3 | 29.1 | 31.6 (0.9) |
Cis | 21.6 | 26.2 (0.6) | 20.1 | 23.8 (0.9) | 29.7 | 13.6 (0.05) | 23.3 | 17.0 (0.4) | 32.8 | 13.7 | 24.7 (0.4) |
Mel | 53.3 | 52.2 (0.9) | 56.1 | 53.1 (0.8) | 52.4 | 53.8 (0.9) | 49.1 | 53.3 (0.9) | 54.8 | 44.2 | 52.9 (0.5) |
5-FU | 539.5 | 475.4 (0.6) | 497.5 | 604.9 (0.4) | 542.1 | 455.5 (0.4) | 521.5 | 426.6 (0.3) | 689.9 | 490.4 | 519.2 (0.9) |
MMC | 19.1 | 22.5 (0.7) | 23.3 | 12.0 (0.3) | 24.6 | 14.2 (0.2) | 12.8 | 20.5 (0.4) | 29.4 | 8.68 | 21.2 (0.3) |
Iri | 131.7 | 163.1 (0.6) | 153.3 | 111.2 (0.5) | 183.9 | 81.1 (0.07) | 122.0 | 163.5 (0.8) | 129.2 | 84.4 | 151.6 (0.5) |
Doce | 15.0 | 21.5 (0.3) | 18.5 | 13.8 (0.4) | 17.2 | 16.6 (0.9) | 16.9 | 17.9 (0.8) | 12.4 | 23.5 | 14.4 (0.1) |
Dox | 2.80 | 2.98 (0.9) | 3.34 | 1.59 (0.1) | 2.96 | 2.78 (0.9) | 1.74 | 3.51 (0.3) | 2.86 | 1.20 | 2.96 (0.3) |