Intestinal-type of differentiation predicts favourable overall survival: confirmatory clinicopathological analysis of 198 periampullary adenocarcinomas of pancreatic, biliary, ampullary and duodenal origin

Table 4 Univariate survival analysis for tumor location and histopathological subtypes in periampullary adenocarcinomas

Location	Type	N	Events	Survival (months)		p
			(Deaths)	Median	Mean
		Comparison of tumor locations versus PDAC
PDAC	ALL	121	64	23	31	-
DBDAC		21	14	29	39	0.430
AMPAC		40	14	64	72	0.000
DUOAC		9	6	71	46	0.169
		Comparison of tumor subtypes versus INT
ALL	INT	37	8	NR	83	-
	MIX	12	8	30	37	0.002
	OTH WHO	6	4	25	38	0.017
	PB	115	66	22	34	0.000
	POOR	21	12	13	28	0.000
	NON-INT	154	90	22	35	0.000
		Comparison INT vs NON-INT stratified for tumor location
PDAC	NON-INT	111	63	20	29	0.034
PDAC	INT	10	1	39	74	0.034
DBDAC	NON-INT	17	12	12	37	0.563
DBDAC	INT	4	2	29	55	0.563
AMPAC	NON-INT	22	11	38	56	0.019
AMPAC	INT	18	3	NR	90	0.019
DUOAC	NON-INT	4	4	4	10	0.003
	INT	5	2	75	75

Survival estimates are derived from Kaplan-Meier method, p values from two-sided Logrank test. For Kaplan-Meier plots see Figure 3. Perioperative deaths (n = 7) were excluded from survival analysis.
Abbreviations: INT intestinal, NON-INT non-intestinal, PB pancreatobiliary subtype, MIX mixed subtype, POOR poorly differentiated carcinoma, OTH other subtypes, PDAC pancreatic ductal adenocarcinoma, DBDAC distal bile duct adenocarcinoma, AMPAC ampullary adenocarcinoma, DUOAC duodenal adenocarcinoma, NR not reached.

ISSN: 1471-2407