Intestinal-type of differentiation predicts favourable overall survival: confirmatory clinicopathological analysis of 198 periampullary adenocarcinomas of pancreatic, biliary, ampullary and duodenal origin

Table 2 Diagnostic value of immunohistochemical markers for intestinal type adenocarcinoma

Location	Marker	% Positive tumor cells		% Correct prediction		p
Location	Marker	Median (Range)		% Correct prediction		p
		INT	NON-INT	INT	NON-INT
PDAC / DBDAC	CK7	90 (0–100)	90 (0–100)	0%	100%	0.288
	CK20	10 (0–100)	0 (0–100)	0%	100%	0.034
	CDX2	45 (0–100)	0 (0–90)	13%	100%	0.000
	CK7, CK20, CDX2	-		19%	100%	0.002
	multivariate	-		19%	100%	0.002
AMPAC / DUOAC	CK7	20 (0–100)	85 (0–100)	57%	75%	0.024
	CK20	80 (0–100)	8 (0–100)	65%	79%	0.002
	CDX2	90 (20–100)	30 (0–100)	87%	79%	0.000
	CK7, CK20, CDX2	-		87%	75%	0.000
	multivariate	-		87%	75%	0.000
ALL	CK7, CK20, CDX2	-		51%	95%	0.000
	multivariate

Prediction modeled by univariate and multivariate binary logistic regression analysis, p values given for the two-sided overall model omnibus test of the respective row.
Abbreviations: PDAC / DBDAC / AMPAC / DUOAC pancreatic ductal/distal bile duct / ampullary / duodenal adenocarcinoma, INT intestinal, NON-INT non-intestinal, CK cytokeratin, CI confidence interval.

ISSN: 1471-2407