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Table 2 Overall Survival according to prognostic factors (upper table: univariate analysis, lower table: multivariate analysis)

From: Clinical complete responders to definite chemoradiation or radiation therapy for oesophageal cancer: predictors of outcome

Prognostic factors

N

n

Median OS [CI 95%]

p

Prognostic factors

N

n

Median OS [CI 95%]

p

Total

110

80

2.5 [1.8–4.1]

      

Age

    

Surgery

    
 

<= 60 y

60

39

2. 5 [1.8–6.0]

0.060

 

No

94

69

2.5 [1.8–4.2]

0.97

 

>60 y

50

41

2. 7 [1.1–4.1]

  

Yes

16

11

2.7 [0.8–…]

 

Gender

    

Albuminemia

    
 

M

98

71

2.5 [1.8–4.1]

0.92

 

<35 g/L

4

4

1.3 [0.5–…]

0.20

 

F

12

9

2.0 [0.7–…]

  

≥35 g/L

46

34

3.3 [1.9–4.9]

 

Histology

    

Dysphagia (baseline)

    
 

Adenocarcinoma

7

7

2.5 [0.6–4.1]

0.17

 

Grade 1–2

44

31

3.0 [1.8 – 4.2]

0.90

 

Squamous cell

103

73

2.7 [1.8–4.2]

  

Grade ≥ 3

65

48

2.7 [1.5–4.4]

 

Tumor site

    

Dysphagia (end of treatment)

    
 

Upper third

41

30

4.2 [2.0–5.8]

0.23

 

Grade 1–2

78

58

3.3 [2.1 – 5.5]

0.0016

 

Middle third

50

35

1.9 [1.2–3.0]

  

Grade ≥ 3

32

28

0.9 [0.6–3.3]

 
 

Lower third

19

15

2.5 [0.7–3.3]

       

Staging

    

Weight loss at baseline

    
 

I/IIA

40

28

3.3 [1.3–5.8]

0.074

 

None

36

22

5.2 [1.8–6.1]

0.20

 

IIB/III

56

41

2.5 [1.5 – 3.8]

  

<10%

45

35

1.9 [1.2–3.0]

 
 

IV

6

6

0.9 [0.7–…]

  

≥10%

29

23

2.5 [1.3–3.6]

 

Chemotherapy

    

Weight loss during treatment

    
 

No

15

11

2.0 [0.7–4.2]

0.36

 

None

35

21

5.5 [2.7–8.6]

0.039

 

Yes

95

69

2.8 [1.8–4.1]

  

<10%

38

28

2.5 [1.5–4.2]

 

Radiation dose

     

≥10%

37

31

1.4 [0.8–2.1]

 
 

≤50.4 Gy

61

41

3.3 [1.8–4.9]

0.45

      
 

>50.4 Gy

49

39

2.0 [1.1–4.2]

       

Prognostic variables

Deaths/N

OS rate [CI 95%] (3y)

Median OS [CI 95%] (y)

HR [CI 95%]

p

Score

Weight loss during treatment

      

None

21/35

63% [45–77]

5.5 [2.7–8.6]

1

 

0

<10%

28/38

46% [29–61]

2.5 [1.5–4.2]

1.5 [0.8–2.6]

0.18

1

≥10%

31/37

32% [18–48]

1.4 [0.8–2.1]

1.8 [1.0–3.2]

0.040

2

Dysphagia (end of treatment)

      

Grade 1–2

52/78

52% [40–63]

3.3 [2.1–5.5]

1

 

0

Grade ≥3

28/32

34% [19–51]

0.9 [0.6–3.3]

1.9 [1.2–3.1]

0.007

2

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