Figure 2

Treatment with APMS-MB-DOX microparticles (0.05 mg/kg) significantly reduces tumor volume and weight. (A) The average tumor volume (mm³), including pooled spheroids, per treatment group is provided (Mean +/- SEM). Treatment with DOX at high concentrations (0.2 mg/kg) or APMS-MB-DOX (0.05 mg/kg) significantly reduced the average tumor volume/mouse compared to saline (*) and APMS-MB (†) controls (p ≤ 0.05). (B) The average tumor weight (gm) is represented for each treatment group (Mean +/- SEM). Treatment with DOX high (0.2 mg/kg) significantly reduced the average tumor weight/mouse compared to saline (*) and APMS-MB (†) controls (p ≤ 0.05). Treatment with APMS-MB-DOX (0.05 mg/kg) significantly reduced tumor weight in comparison to the APMS-MB group (†).