Table 4 Association of allele and genotype frequencies within selected breast cancer subgroups

OPG rs2073618

G

C

GG

CG

CC

 Invasive tumors

316 (57.5%)

234 (42.5%)

86 (31.3%)

144 (52.4%)

45 (16.4%)

 Non-invasive tumors

22 (39.3%)

34 (60.7%)

6 (21.4%)

10 (35.7%)

12 (42.9%)

 OR (95%CI) p-value*

2.088 (1.189-3.663) p=0.011

p=0.006

RANK rs35211496

T

C

TT

TC

CC

 right breast^a

62 (25.2%)

184 (74.8%)

9 (7.3%)

44 (35.8%)

70 (56.9)

 left breast^a

53 (15.3%)

293 (84.7%)

3 (1.7%)

47 (27.2%)

123 (71.1%)

 OR (95%CI) p-value*

1.863 (1.236-2.808) p=0.003

p=0.009

RANKL rs9533156

C

T

CC

CT

TT

 BMI >/=28

70 (50.7%)

68 (49.3%)

22 (31.9%)

26 (37.7%)

21 (30.4%)

 BMI <28

120 (40%)

180 (60%)

24 (16.0%)

72 (48.0%)

54 (36.0%)

 OR (95%CI) p-value*

1.543 (1.029-2.315) p=0.038

p=0.032

RANKL rs1054016

T

G

TT

TG

GG

 BMI >/=28

66 (47.8%)

72 (52.2%)

20 (29.0%)

26 (37.7%)

23 (33.3%)

 BMI <28

108 (36.0%)

192 (64.0%)

19 (12.7%)

70 (46.7%)

61 (40.7%)

 OR (95%CI) p-value*

1.630 (1.083-2.453) p=0.021

p=0.018