Table 3 Association of allele and genotype frequencies of OPG , RANK and RANKL in patients with breast cancer and healthy controls

OPG rs3102735

n=614 (%)

n=784 (%)

Alleles

C

113 (18.4%)

102 (13.0%)

1.508

0.006

T

501 (81.6%)

682 (87.0%)

(1.127-2.018)

n=307 (%)

n=392 (%)

Genotypes

CC

10 (3.3%)

5 (1.3%)

0.019

CT

93 (30.3%)

92 (23.5%)

TT

204 (66.4%)

295 (75.3%)

OPG rs2073618

n=614 (%)

n=786 (%)

Alleles

C

269 (43.8%)

357 (45.4%)

0.937

0.552

G

345 (56.2%)

429 (54.6%)

(0.758-1.159)

n=307 (%)

n=393 (%)

Genotypes

CC

57 (18.6%)

77 (19.6%)

0.810

CG

155 (50.5%)

203 (51.7%)

GG

95 (30.9%)

113 (29.7%)

RANK rs1805034

n=614 (%)

n=790 (%)

Alleles

C

291 (47.4%)

362 (45.8%)

1.065

0.590

T

323 (52.6%)

428 (54.2%)

(0.862-1.316)

n=307 (%)

n=395 (%)

Genotypes

CC

73 (23.8%)

78 (19.7%)

0.334

CT

145 (47.2%)

206 (52.2%)

TT

89 (29.0%)

111 (28.1%)

RANK rs35211496

n=614 (%)

n=792 (%)

Alleles

T

122 (19.9%)

141 (17.8%)

1.145

0.335

C

492 (80.1%)

651 (82.2%)

(0.875-1.499)

n=307 (%)

n=396 (%)

Genotypes

TT

12 (3.9%)

9 (2.3%)

0.423

TC

98 (31.9%)

123 (31.1%)

CC

197 (64.2%)

264 (66.7%)

RANKL rs9533156

n=614 (%)

n=788 (%)

Alleles

C

280 (45.6%)

369 (46.8%)

0.952

0.666

T

334 (54.4%)

419 (53.2%)

(0.770-1.176)

n=307 (%)

n=394 (%)

Genotypes

CC

68 (22.1%)

82 (20.8%)

0.387

CT

144 (46.9%)

205 (52.0%)

TT

95 (30.9%)

107 (27.2%)

RANKL rs2277438

n=614 (%)

n=788 (%)

Alleles

G

109 (17.8%)

132 (16.8%)

1.073

0.669

A

505 (82.2%)

656 (83.2%)

(0.812-1.418)

n=307 (%)

n=394 (%)

Genotypes

GG

8 (2.6%)

9 (2.3%)

0.866

GA

93 (30.3%)

114 (28.9%)

AA

206 (67.1%)

271 (68.8%)

RANKL rs1054016

n=614 (%)

n=786 (%)

Alleles

T

258 (42.0%)

345 (43.9%)

0.927

0.514

G

356 (58.0%)

441 (56.1%)

(0.749-1.147)

n=307 (%)

n=393 (%)

Genotypes

TT

57 (18.6%)

73 (18.6%)

0.543

TG

144 (46.9%)

199 (50.6%)

GG

106 (34.5%)

121 (30.8%)