Base case | Sensitivity analysis | References | ||
---|---|---|---|---|
Parameter | Lower limit | Upper limit | ||
Kidney cancer incidence 40+ (per 100,000) | 19.8 | 17.82 | 21.78 | [22] |
RCC incidence (over kidney cancer incidence) | 90% | 85% | 95% | |
RCC incidence at diagnosis (over RCC incidence) | 20% | 15% | 25% | |
RCC mortality (localized disease) | 1.66% | 1.49% | 1.83% | [23] |
Transition to advanced RCC (year 1) | 13.18% | 11.86% | 14.49% | [20] |
Transition to advanced RCC (years 2 and 3) | 4.57% | 4.11% | 5.02% | [20] |
Transition to advanced RCC (years 4 and 5) | 1.92% | 1.73% | 2.11% | [20] |
Transition to advanced RCC (year 6 and 7) | 1.64% | 1.48% | 1.81% | [20] |
Transition to advanced RCC (year 8 to 10) | 1.26% | 1.13% | 1.38% | [20] |
Advanced RCC of favorable or intermediate risk | 89% | 80.1% | 97.9% | [26] |
Transition to post-advanced RCC | 100% |