IGF-1 receptor and IGF binding protein-3 might predict prognosis of patients with resectable pancreatic cancer

BMC Cancer

Table 2 Association between IGF1R & IFGBP3 expression and clinicopathological factors in resectable pancreatic cancer

	IGF1R expression			IGFBP3 expression			Both IGF1R (+) and IGFBP3 (−)
Characteristics	positive	negative		positive	negative		positive	others
	n = 50	n = 72	p-value	n = 37	n = 85	p-value	n = 32	n = 90	p-value
Age
<60	7	18		10	15		3	22
≧60	43	54	0.139	27	70	0.238	29	68	0.07
Gender
Male	25	31		15	41		16	40
Female	25	41	0.449	22	44	0.433	16	50	0.588
T category
T1, T2	9	17		7	19		3	23
T3, T4	41	55	0.457	30	66	0.670	29	67
N category									0.077
N0	23	33		20	36		14	42
N1	27	39	0.986	17	49	0.233	18	48	0.776
Stage
I	4	11		5	10		0	15
II & III	46	61		32	75		32	75
Tumor location			0.273			0.787			0.011
proximal	31	50		30	51		18	63
distal	19	22		7	34		14	27
Tumor differentiation			0.392			0.023			0.157
Grade1, 2	46	56		34	68		28	74
Grade 3, 4	4	16	0.037	3	17	0.082	4	16	0.588
Lymphatic invasion
negative	24	42		19	47		15	51
positive	26	30	0.260	18	38	0.688	17	39	0.340
Arterial invasion
negative	43	67		33	77		27	83
positive	7	5	0.198	4	8	0.754	5	7	0.200
Venous invasion
negative	45	62		36	71		28	79
positive	5	10	0.52	1	14	0.037	4	11	0.967
Intrapancreatic nerve invasion
negative	21	38		16	43		16	43
positive	29	34	0.241	21	42	0.456	16	47	0.829
Tumor stromal volume
med & int	31	55		27	59		19	67
sci	19	17	0.087	10	26	0.692	13	23	0.108
IGFBP3 expression
negative	32	53
positive	18	19	0.256

Medullary type (med): scanty stroma, Intermediate type (int): the quantity of stroma is intermediate between the two above types, Scirrhous type (sci): abundant stroma.

ISSN: 1471-2407