Combination of carbonic anhydrase inhibitor, acetazolamide, and sulforaphane, reduces the viability and growth of bronchial carcinoid cell lines

Table 4 The percentage of 5-HT content of tumor cells within H-727 and H-720 Xenografts after treatment with AZ and/or SFN

Cell Type	Treatment	% 5-HT content Compared to Control	* P-value	† P-value
H-727	AZ	22 +/− 1.2	p < 0.001	p < 0.01
	SFN	14 +/− 2.7	p < 0.05	p < 0.05
	AZ + SFN	59 +/− 7.9	p < 0.0001	-
H-720	AZ	19 +/− 9	p < 0.001	p < 0.0001
H-720	SFN	19 +/− 6.2	p < 0.001	p < 0.0001
	AZ + SFN	45 +/− 3.4	p < 0.001	p < 0.0001

* P-value was measured by comparing treated tumor to untreated tumor.
† P-value was measured by comparing single agent treatment to a combination treatment.

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