Table 1 Dose-dependent inhibition of growth of lung Carcinoid cell lines with AZ and/or SFN treatment alone (Short Term (48 hours) and long term (7 days)
| Â | Short term | Long term | Â | ||||
|---|---|---|---|---|---|---|---|
Cell line | Drug | Concentration (μM); 48 h | % Growth inhibition; 48 h | Concentration (μM); 7D | % Growth inhibition; 7D | IC50(μM); 7D | |
H-727 | AZ | Min | 40 | 16 +/− 6.2 | 5 | 3 +/− 6.4 | 117.5 |
Max | 80 | 19 +/− 6.2 | 80 | 35 +/− 3.6 | |||
SFN | Min | 10 | 10 +/− 1.1 | 5 | 17 +/− 2 | 11.3 | |
Max | 80 | 23 +/− 7 | 80 | 26 +/− 0.4 | |||
AZ+ | Min | 10 | 13 +/− 3.4 | 2.5 | 11 +/− 4 | 6.75 | |
SFN | Max | 80 | 25 +/− 7 | 80 | 98 +/− 0.5 | ||
H-720 | AZ | Min | - | - | 40 | 15 +/− 4.1 | 166.5 |
Max | - | - | 80 | 37 +/− 5.1 | |||
SFN | Min | 10 | 15 +/− 1.6 | 10 | 25 +/− 1.6 | 25.1 | |
Max | 80 | 36 +/− 1 | 80 | 85 +/− 0.5 | |||
AZ+ | Min | 10 | 15 +/− 1.5 | 10 | 32 +/− 1.9 | 18.65 | |
SFN | Max | 80 | 39 +/− 0.7 | 80 | 90 +/− 0.3 | ||
FLF | AZ | Min | - | - | 10 | 8 +/− 1.1 | 514.4 |
Max | - | - | 80 | 24 +/− 2.8 | |||
SFN | Min | - | - | 5 | 5 +/− 1.2 | 39.54 | |
Max | - | - | 80 | 82 | |||
AZ+ | Min | - | - | 5 | 13 +/− 2.6 | 29.68 | |
|  | SFN | Max | - | - | 80 | 95 +/− 2.4 |  |