Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Table 1 Cell line panel representing different types of drug resistance

Cell line	Diagnosis	Selective agent	Mechanism of resistance	P-gp expression*	Reference
RPMI 8226	Myeloma			82
8226/Dox40	Myeloma	Doxorubicin	P-gp170	27002	[11, 15]
8226/LR5	Myeloma	Melphalan	GSH associated	Not expressed**	[16]
CCRF-CEM	T-cell leukemia			Not expressed**
CEM/VM-1	T-cell leukemia	Teniposode	Topo II associated	Not expressed**	[17]
NCI-H69	Small cell lung cancer			Not expressed**
H69AR	Small cell lung cancer	Doxorubicin	MRP associated	Not expressed**	[18]
U-937	Histiocytic lymphoma			Not expressed**
U-937-vcr	Histiocytic lymphoma	Vincristine	Tubulin associated	875	[19]

*mRNA gene expression, probe ID 209993_at (ABCB1 P-gp), (Affymetrix, Inc.).
**Gene expression not detected, absent call according to MAS5 (Affymetrix, Inc.).

ISSN: 1471-2407