Functional promoter -31G/C variant of Survivin gene predict prostate cancer susceptibility among Chinese: a case control study

Table 4 Associations of the the BIRC5 rs9904341 polymorphisms with the clinicopathological characteristics of PCa

Variables	Genotypes, n (%)		P ^*	Adjusted OR (95%CI) ^*
	GG	CG + CC		CG + CC versus GG
Clinical Stage^†			0.260
Localized	94 (24.1)	296 (75.9)		1.00 (reference)
Advanced	56 (20.3)	219 (79.6)		1.23 (0.85-1.79)
Gleason Score			0.534
<7	55 (24.4)	170 (75.6)		1.00 (reference)
=7	51 (23.1)	170 (76.9)		1.10 (0.71-1.71)
>7	44 (20.1)	175 (79.9)		1.26 (0.80-1.98)
PSA(ng /ml)			0.010
≤20	75 (27.6)	197 (72.4)		1.00 (reference)
>20	75 (19.1)	318 (80.9)		1.62 (1.12-2.33)

^* The P value and ORs were calculated and adjusted for age, smoking, drinking, and family history of cancer in logistic regression model; 95% CI: 95% confidence interval; OR: odds ratio.
^†Localized: T_{1- 2}N₀M₀; Advanced: T_3-4N_xM_x or T_xN₁M_x or T_xN_xM₁. Clinical staging according to the international TNM system for PCa.

ISSN: 1471-2407