Functional promoter -31G/C variant of Survivin gene predict prostate cancer susceptibility among Chinese: a case control study

Table 3 Stratification analyses between the genotypes of rs9904341 G > C polymorphism and risk of PCa

Variables	Cases/Controls	Genotypes(Cases/Controls)				P*	Adjusted OR(95%CI) ^†
		GG		GC + CC
		n	%	n	%		GC + CC versus GG
Total	665/710	150/205	22.5/28.9	515/505	77.5/71.1	0.008	1.40 (1.09-1.80)
Age
≤ 71	310/355	66/98	21.3/27.6	244/257	78.7/72.4	0.060	1.35 (0.93-1.95)
> 71	355/355	84/107	23.7/30.1	271/248	76.3/69.9	0.052	1.44 (1.02- 2.01)
Smoking status
Never	280/353	62/105	22.1/29.8	218/248	77.9/70.2	0.031	1.47 (1.01-2.12)
Ever	385/357	88/100	22.9/28.0	297/257	77.1/72.0	0.109	1.35 (0.96-1.89)
Pack-years of smoking
0-20	128/177	37/49	28.9/27.7	91/128	71.1/72.3	0.899	0.94 (0.52-1.57)
> 20	257/180	52/51	20.2/28.3	205/129	79.8/71.7	0.050	1.56 (0.99-2.58)
Drinking status
Never	468/537	109/159	23.3/29.6	359/378	76.7/70.4	0.024	1.37 (1.02-1.83)
Ever	197/173	41/46	20.8/26.6	156/127	79.2/73.4	0.191	1.46 (0.89-2.38)
Family history of cancer
No	536/655	121/187	22.6/28.6	415/468	77.4/71.4	0.019	1.36 (1.04-1.77)
Yes	126/55	29/18	22.5/32.7	100/37	77.5/62.3	0.145	1.60 (0.79-3.25)

*Two-sided χ² test for either genotype distributions or allele frequencies between the cases and controls.
^† Adjusted for age, smoking status, drinking status and family history of cancer in logistic regression model; 95% CI: 95% confidence interval.

ISSN: 1471-2407